MICB
MICB，全稱為MHC class I polypeptide-related sequence B，是一種跨膜糖蛋白，屬于人組織相容性復合體I類相關基因家族。該蛋白常見別名包括MHC class I antigen-related protein B、MHC class I chain-related protein B等。MICB蛋白在正常細胞中表達量極低，主要在上皮性腫瘤細胞表面表達，并且可以被細菌和病毒感染誘導表達。因此，MICB蛋白的識別與腫瘤監測、病毒感染和自身免疫性疾病的預防密切相關。
MICB蛋白作為人NKG2D II 型受體的配體，能夠與NK細胞表面的NKG2D受體結合，從而激活NK細胞的殺傷活性。這一作用機制使得MICB蛋白在免疫系統中扮演著重要的角色，能夠幫助機體清除異常細胞。此外，MICB蛋白的表達水平與多種疾病的發生發展密切相關，如消化系腫瘤、終末期腎病等。在藥物研發方面，針對MICB蛋白的靶向治療正在積極探索中，以期開發出更加有效的腫瘤治療藥物。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human MICB at 2 μg/ml can bind Anti-MICA/B recombinant antibody (CSB-RA56059MA1HU). The EC50 is 1.087-1.369 ng/mL.
Human MHC class I polypeptide-related sequence B(MICB) ELISA kit (CSB-EL013813HU)
驗證數據
貨號：CSB-EL013813HU
規格：96T/48T
靈敏度：7.8 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MICB Proteins
MICB Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-BP013813HU CSB-EP013813HU-B |
Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP000271HU | Recombinant Human MHC class I polypeptide-related sequence B protein (MICB) | E.Coli |
| CSB-MP013813HU | Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial | Mammalian cell |
| CSB-EP013813HU | Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial | E.coli |
| CSB-YP013813HU | Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial | Yeast |
| CSB-MP013813HUd7 | Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial (Active) | Mammalian cell |
MICB ELISA Kit
MICB ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL013813HU | Human MHC class I polypeptide-related sequence B(MICB) ELISA kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
