METAP2
METAP2，即甲硫氨酰氨肽酶2，別名MAP2、MNPEP、p67、Peptidase M等。它是一種在所有生物體中存在的酶，具有關鍵的組織修復和蛋白質降解功能。METAP2的作用機制主要是在蛋白質合成過程中，共翻譯地移除新生多肽鏈上的N-末端甲硫氨酸，這一過程對于蛋白質的成熟和功能發揮至關重要。特別是，當多肽鏈的第二個殘基是小的非極性氨基酸時，如丙氨酸、半胱氨酸、甘氨酸、脯氨酸、絲氨酸、蘇氨酸或纈氨酸，METAP2的催化活性會顯著提高 。METAP2在生物學上的意義非常廣泛，它不僅參與了蛋白質合成的調控，還與多種生物學過程相關，包括血管生成、細胞增殖和腫瘤發展等。由于在血管生成中的關鍵作用，METAP2成為了治療某些疾病如實體瘤癌癥和類風濕性關節炎的潛在靶點。此外，METAP2的抑制劑，例如Fumagillin和Ovalicin，已被研究用于抗癌藥物的開發，并且有研究顯示，針對METAP2的抑制劑還能夠有效治療肥胖癥 。
熱銷產品
Recombinant Human Methionine aminopeptidase 2 (METAP2) (CSB-EP013716HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013716HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) METAP2.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013716HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) METAP2.
METAP2 Recombinant Monoclonal Antibody (CSB-RA294332A0HU)
驗證數據
IHC image of CSB-RA294332A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
METAP2 Antibodies
METAP2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA013716GA01HU | METAP2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA013716LA01HU | METAP2 Antibody | Human, Rat | ELISA, WB, IHC, IF |
| CSB-PA013716LB01HU | METAP2 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA294332A0HU | METAP2 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
METAP2 Proteins
METAP2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013716HU | Recombinant Human Methionine aminopeptidase 2 (METAP2) | Yeast |
| CSB-EP013716HU | Recombinant Human Methionine aminopeptidase 2 (METAP2) | E.coli |
| CSB-BP013716HU CSB-MP013716HU CSB-EP013716HU-B |
Recombinant Human Methionine aminopeptidase 2 (METAP2) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
