MC2R
MC2R是黑素皮質(zhì)素受體2的簡稱，全稱為黑色素皮質(zhì)素II型受體。該受體主要參與應(yīng)激反應(yīng)的下丘腦-垂體-腎上腺軸的調(diào)節(jié)，對促腎上腺皮質(zhì)激素（ACTH）具有高度特異性。MC2R的功能依賴于輔助蛋白MRAP1，MRAP1不僅幫助MC2R運輸?shù)劫|(zhì)膜，還對其產(chǎn)生活性至關(guān)重要。MC2R在生理狀態(tài)下刺激糖皮質(zhì)激素生成和皮質(zhì)醇分泌，其功能障礙會導(dǎo)致糖皮質(zhì)激素不足疾病，如家族性糖皮質(zhì)激素缺乏癥（FGD），或皮質(zhì)醇過多癥，如先天性腎上腺增生癥（CAH）和庫欣綜合征（CS）。近年來，科學(xué)家們利用冷凍電鏡技術(shù)解析了MC2R與MRAP1、ACTH及下游Gs蛋白復(fù)合物的三維結(jié)構(gòu)，揭示了MC2R對ACTH特異的分子識別機制，為理解多肽激素調(diào)控MC2R的生理過程提供了新的思路，也為靶向MC2R的藥物設(shè)計提供了啟示。目前，已有研究機構(gòu)開始探索MC2R激動劑和抑制劑的開發(fā)，以治療相關(guān)的腎上腺皮質(zhì)疾病。
熱銷產(chǎn)品
驗證數(shù)據(jù)
Western Blot analysis of HeLa cells using MC2-R Polyclonal Antibody
MC2R Antibodies
MC2R for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA003204 | MC2R Antibody | Human,Mouse | WB, IF, ELISA |
| CSB-PA214837 | MC2R Antibody | Human,Mouse | ELISA,WB |
MC2R Proteins
MC2R Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013559BO1 CSB-EP013559BO1 CSB-BP013559BO1 CSB-MP013559BO1 CSB-EP013559BO1-B |
Recombinant Bovine Adrenocorticotropic hormone receptor (MC2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013559BO | Recombinant Bovine Adrenocorticotropic hormone receptor (MC2R) | in vitro E.coli expression system |
MC2R Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013559MRG1 CSB-EP013559MRG1 CSB-BP013559MRG1 CSB-MP013559MRG1 CSB-EP013559MRG1-B |
Recombinant Mesocricetus auratus Adrenocorticotropic hormone receptor (MC2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013559MRG | Recombinant Mesocricetus auratus Adrenocorticotropic hormone receptor (MC2R) | in vitro E.coli expression system |
MC2R Proteins for Papio hamadryas (Hamadryas baboon)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP636746ERJ CSB-EP636746ERJ CSB-BP636746ERJ CSB-MP636746ERJ CSB-EP636746ERJ-B |
Recombinant Papio hamadryas Adrenocorticotropic hormone receptor (MC2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MC2R Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP723737MO1 CSB-EP723737MO1 CSB-BP723737MO1 CSB-MP723737MO1 CSB-EP723737MO1-B |
Recombinant Mouse Adrenocorticotropic hormone receptor (Mc2r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF723737MO | Recombinant Mouse Adrenocorticotropic hormone receptor (Mc2r) | in vitro E.coli expression system |
MC2R Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP810231PI1 CSB-EP810231PI1 CSB-BP810231PI1 CSB-MP810231PI1 CSB-EP810231PI1-B |
Recombinant Pig Adrenocorticotropic hormone receptor (MC2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF810231PI | Recombinant Pig Adrenocorticotropic hormone receptor (MC2R) | in vitro E.coli expression system |
MC2R Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP890597SH1 CSB-EP890597SH1 CSB-BP890597SH1 CSB-MP890597SH1 CSB-EP890597SH1-B |
Recombinant Sheep Adrenocorticotropic hormone receptor (MC2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF890597SH | Recombinant Sheep Adrenocorticotropic hormone receptor (MC2R) | in vitro E.coli expression system |
