MAG

髓鞘相關(guān)糖蛋白（Myelin-associated glycoprotein，MAG）是中樞神經(jīng)系統(tǒng)髓鞘的重要組成部分，也被稱為Siglec-4a。它由少突膠質(zhì)細(xì)胞分泌，主要分布在髓鞘最內(nèi)層，通過與神經(jīng)元表面神經(jīng)節(jié)苷脂GD1a/GT1b結(jié)合，在維持軸突髓鞘結(jié)構(gòu)穩(wěn)定中起關(guān)鍵作用。MAG具有抑制神經(jīng)再生的特性，尤其在脊髓損傷后，MAG與Nogo受體結(jié)合后激活下游信號，可阻礙受損軸突的延伸，這一特性使其成為神經(jīng)修復(fù)研究的重點(diǎn)靶點(diǎn)。
MAG異常表達(dá)與多發(fā)性硬化、脊髓損傷后遺癥等脫髓鞘疾病密切相關(guān)，其過度抑制作用可能加劇神經(jīng)功能障礙。近年針對MAG的抗體藥物開發(fā)取得進(jìn)展，例如通過阻斷MAG與其受體的相互作用來促進(jìn)神經(jīng)再生。目前相關(guān)小分子抑制劑和單抗已進(jìn)入臨床前評估階段，為治療中樞神經(jīng)損傷提供了新方向。阿爾茨海默病患者腦脊液中檢測到MAG水平異常升高，提示其可能參與神經(jīng)退行性病變過程。

熱銷產(chǎn)品

Recombinant Human Myelin-associated glycoprotein (MAG), partial (CSB-EP013322HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013322HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MAG.

MAG Antibody (CSB-PA013322LA01HU)

驗(yàn)證數(shù)據(jù)

Immunofluorescence staining of MCF-7 cells with CSB-PA013322LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Western Blot
Positive WB detected in: K562 whole cell lysate, Jurkat whole cell lysate, Rat brain tissue, Mouse brain tissue
All lanes: MAG antibody at 5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70, 64, 67 kDa
Observed band size: 70, 100 kDa

IHC image of CSB-PA013322LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA013322LA01HU diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human myelin-associated glycoprotein(MAG) ELISA Kit (CSB-E17901h)

驗(yàn)證數(shù)據(jù)

貨號：CSB-E17901h

規(guī)格：96T/48T

靈敏度：0.156 ng/mL

檢測范圍：0.625 ng/mL-40 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

MAG Antibody

MAG Protein

MAG ELISA Kit

MAG Antibodies

MAG for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA013322LD01HU	MAG Antibody, Biotin conjugated	Human	ELISA
CSB-PA013322LC01HU	MAG Antibody, FITC conjugated	Human
CSB-PA013322LA01HU	MAG Antibody	Human, Mouse, Rat	ELISA, WB, IHC, IF
CSB-PA006022	MAG Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA951068	MAG Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA643161	MAG Antibody	Human,Mouse,Rat	ELISA,WB,IHC

MAG Proteins

MAG Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP013322HU	Recombinant Human Myelin-associated glycoprotein (MAG), partial	Yeast
CSB-EP013322HU	Recombinant Human Myelin-associated glycoprotein (MAG), partial	E.coli
CSB-BP013322HU CSB-MP013322HU CSB-EP013322HU-B	Recombinant Human Myelin-associated glycoprotein (MAG), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP013322HUa0	Recombinant Human Myelin-associated glycoprotein (MAG), partial	E.coli

MAG Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP013322MO1 CSB-EP013322MO1 CSB-BP013322MO1 CSB-MP013322MO1 CSB-EP013322MO1-B	Recombinant Mouse Myelin-associated glycoprotein (Mag), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF013322MO	Recombinant Mouse Myelin-associated glycoprotein (Mag)	in vitro E.coli expression system

MAG Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP013322RA1 CSB-EP013322RA1 CSB-BP013322RA1 CSB-MP013322RA1 CSB-EP013322RA1-B	Recombinant Rat Myelin-associated glycoprotein (Mag), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF013322RA	Recombinant Rat Myelin-associated glycoprotein (Mag)	in vitro E.coli expression system

MAG Proteins for Dermatophagoides farinae (American house dust mite)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP336609DCO CSB-EP336609DCO CSB-BP336609DCO CSB-MP336609DCO CSB-EP336609DCO-B	Recombinant Dermatophagoides farinae Allergen Mag (MAG)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAG Proteins for Arabidopsis thaliana (Mouse-ear cress)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP654399DOA CSB-EP654399DOA CSB-BP654399DOA CSB-MP654399DOA CSB-EP654399DOA-B	Recombinant Arabidopsis thaliana DNA-3-methyladenine glycosylase (MAG)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAG Proteins for Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP836836DWY CSB-EP836836DWY CSB-BP836836DWY CSB-MP836836DWY CSB-EP836836DWY-B	Recombinant Corynebacterium glutamicum Putative 3-methyladenine DNA glycosylase (mag)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli