LRRC15
LRRC15，全稱富含亮氨酸重復序列的蛋白15，也被稱為LIB和hLib。該蛋白在多種實體瘤中高表達，特別是在乳腺癌、頭頸部、肺癌、胰腺癌等腫瘤的基質(zhì)成纖維細胞上表達，同時在間充質(zhì)來源的癌細胞亞群，如肉瘤、黑色素瘤、膠質(zhì)母細胞瘤中也有表達。LRRC15的表達受TGF-β調(diào)控，在活化的成纖維細胞和間充質(zhì)干細胞中誘導表達。作為治療LRRC15陽性基質(zhì)纖維增生癌癥或間充質(zhì)來源癌癥的靶點，LRRC15已成為腫瘤治療領(lǐng)域的研究熱點。目前，多家藥企已開發(fā)出針對LRRC15的抗體偶聯(lián)藥物（ADC），如艾伯維的ABBV-085和第一三共的LRRC15 ADC專利藥物，均顯示出良好的臨床前療效。此外，LRRC15在雙特異性T細胞銜接器和放射性核素治療領(lǐng)域也展現(xiàn)出重要潛力，進一步拓展了該靶點的治療應(yīng)用場景。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human LRRC15 at 2 μg/ml on an Nickel Coated plate can bind Anti-LRRC15 recombinant antibody (CSB-RA819484MA1HU). The EC50 is 12.18-15.75 ng/mL.
Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial (CSB-MP819484HUd9)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LRRC15 Antibody (CSB-PA819484LA01HU)
驗證數(shù)據(jù)
Immunofluorescence staining of SH-SY5Y cells with CSB-PA819484LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA819484LA01HU at dilution of 1:100
LRRC15 Antibodies
LRRC15 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA191838 | LRRC15 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA206609 | LRRC15 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA819484LA01HU | LRRC15 Antibody | Human | ELISA, IHC, IF |
| CSB-PA819484LB01HU | LRRC15 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA819484LC01HU | LRRC15 Antibody, FITC conjugated | Human | |
| CSB-PA819484LD01HU | LRRC15 Antibody, Biotin conjugated | Human | ELISA |
LRRC15 Proteins
LRRC15 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP819484HU CSB-BP819484HU CSB-EP819484HU-B |
Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP819484HU | Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial | E.coli |
| CSB-MP819484HU | Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial (Active) | Mammalian cell |
| CSB-MP819484HUd9 | Recombinant Human Leucine-rich repeat-containing protein 15 (LRRC15), partial | Mammalian cell |
