LINGO1
LINGO1全稱為富含亮氨酸重復序列和免疫球蛋白樣結構域蛋白1,也被稱為LRR蛋白家族成員或神經元再生抑制因子。LINGO1在神經系統中具有獨特的調節功能,特別是在神經元生長和髓鞘形成過程中扮演"剎車"角色。LINGO1通過阻礙神經突觸延伸和抑制少突膠質細胞分化,顯著影響中樞神經系統的自我修復能力。這種特性使其與帕金森病、特發性震顫等運動障礙類疾病產生關聯,部分患者的基因變異可能加劇神經退行性病變進程。
近年來針對LINGO1的抑制劑開發取得突破性進展,多款單克隆抗體藥物已進入臨床試驗階段。其中抗-LINGO1抗體在動物模型中展現出促進髓鞘再生的潛力,二期臨床數據顯示其對多發性硬化癥患者的神經功能恢復具有改善趨勢。此外,小分子化合物篩選工作聚焦于阻斷其與受體間的特異性結合,為阿爾茨海默病等退行性疾病的治療開辟了新路徑。該靶點的雙重調節特性使其成為神經保護和再生醫學領域的熱門研究對象。
熱銷產品
驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LINGO1 Antibody (CSB-PA839321ESR2HU)
驗證數據

Western blot
All lanes: LINGO antibody at 3.12μg/ml
Lane 1: Mouse lung tissue
Lane 2: Jurkat whole cell lysate
Lane 3: A549 whole cell lysate
Lane 4: HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA839321ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human glioma using CSB-PA839321ESR2HU at dilution of 1:100
LINGO1 Antibodies
LINGO1 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA012967GA01HU | LINGO1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA839321ESR2HU | LINGO1 Antibody | Human, Mouse | ELISA, WB, IHC |
LINGO1 Proteins
LINGO1 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP839321HU CSB-BP839321HU CSB-MP839321HU CSB-EP839321HU-B |
Recombinant Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP839321HU | Recombinant Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1), partial | E.coli |