LGR4
LGR4全稱為富含亮氨酸重復序列的G蛋白偶聯受體4，也被稱為GPR48，是人體內調控多種生理過程的關鍵受體蛋白。該蛋白通過與R-spondin家族蛋白結合，激活Wnt/β-catenin信號系統，參與胚胎發育、干細胞自我更新及組織再生等核心生命活動。LGR4在腸道隱窩細胞增殖、骨骼代謝和生殖系統發育中具有重要作用，其功能異常可能導致結直腸癌、骨質疏松癥及不孕癥等疾病。例如，結直腸癌患者中常出現LGR4過度表達，通過激活Wnt通路驅動腫瘤生長；而基因敲除小鼠模型則顯示骨密度顯著下降。
近年來針對LGR4的藥物開發聚焦于其配體相互作用環節，已有研究團隊設計出阻斷R-spondin與LGR4結合的小分子化合物，在動物實驗中顯示出抑制腫瘤生長的潛力。同時，基于LGR4在代謝調控中的作用，研究人員正探索其在糖尿病和肥胖治療中的應用價值。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LGR4 Antibody (CSB-PA883618LA01HU)
驗證數據
IHC image of CSB-PA883618LA01HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with CSB-PA883618LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
LGR4 Antibodies
LGR4 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA030195 | LGR4 Antibody | Human | WB, IF, ELISA |
| CSB-PA790514 | LGR4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA883618LA01HU | LGR4 Antibody | Human | ELISA, IHC, IF |
| CSB-PA883618LB01HU | LGR4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA883618LC01HU | LGR4 Antibody, FITC conjugated | Human |
LGR4 Proteins
LGR4 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012905MO CSB-EP012905MO CSB-BP012905MO CSB-MP012905MO CSB-EP012905MO-B |
Recombinant Mouse Leucine-rich repeat-containing G-protein coupled receptor 4 (Lgr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LGR4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP883618HU CSB-MP883618HU CSB-EP883618HU-B |
Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), partial | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP883618HU | Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), partial | Baculovirus |
