LGMN
LGMN，全稱為L(zhǎng)GMN（Lysyl-tRNA synthetase interacting protein 1），是一種參與蛋白質(zhì)合成的重要調(diào)控蛋白。該蛋白也被稱為L(zhǎng)ysRS-interacting protein 1，主要在細(xì)胞核內(nèi)發(fā)揮作用，通過與其他蛋白的相互作用影響翻譯過程。LGMN蛋白在多種細(xì)胞活動(dòng)中扮演關(guān)鍵角色，包括細(xì)胞增殖、分化和凋亡。研究表明，LGMN蛋白的表達(dá)水平與多種疾病密切相關(guān)，尤其是癌癥和自身免疫性疾病。在癌癥中，LGMN蛋白的異常表達(dá)可能促進(jìn)腫瘤生長(zhǎng)和轉(zhuǎn)移；而在自身免疫性疾病中，LGMN蛋白的失調(diào)則可能加劇炎癥反應(yīng)。
近年來，針對(duì)LGMN蛋白的藥物研發(fā)取得了一定進(jìn)展。由于其在疾病發(fā)生發(fā)展中的重要作用，LGMN蛋白成為藥物設(shè)計(jì)的潛在靶點(diǎn)。目前，已有多種靶向LGMN蛋白的小分子抑制劑進(jìn)入臨床試驗(yàn)階段，旨在通過抑制其功能來治療癌癥和自身免疫性疾病。例如，某款正在研發(fā)的靶向LGMN蛋白的抗體藥物，在早期臨床試驗(yàn)中顯示出良好的抗腫瘤活性，為患者提供了新的治療選擇。隨著研究的深入，LGMN蛋白有望成為未來藥物研發(fā)的重要方向。
熱銷產(chǎn)品
Recombinant Human Legumain (LGMN) (CSB-EP012903HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LGMN Antibody (CSB-PA012903LA01HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA012903LA01HU diluted at 1:600 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA012903LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Human Legumain(LGMN) ELISA kit (CSB-EL012903HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL012903HU
規(guī)格：96T/48T
靈敏度：15.6 pg/mL
檢測(cè)范圍：62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
LGMN Antibodies
LGMN for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012903LA01HU | LGMN Antibody | Human | ELISA, IHC |
| CSB-PA012903LB01HU | LGMN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012903LC01HU | LGMN Antibody, FITC conjugated | Human | |
| CSB-PA012903LD01HU | LGMN Antibody, Biotin conjugated | Human | ELISA |
LGMN Proteins
LGMN Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012903MO | Recombinant Mouse Legumain (Lgmn) | Yeast |
| CSB-EP012903MO | Recombinant Mouse Legumain (Lgmn) | E.coli |
| CSB-BP012903MO CSB-MP012903MO CSB-EP012903MO-B |
Recombinant Mouse Legumain (Lgmn) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LGMN Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012903PYX CSB-EP012903PYX CSB-BP012903PYX CSB-MP012903PYX CSB-EP012903PYX-B |
Recombinant Pongo abelii Legumain (LGMN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LGMN Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012903BO CSB-EP012903BO CSB-BP012903BO CSB-MP012903BO CSB-EP012903BO-B |
Recombinant Bovine Legumain (LGMN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LGMN Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012903HU | Recombinant Human Legumain (LGMN) | Yeast |
| CSB-EP012903HU | Recombinant Human Legumain (LGMN) | E.coli |
| CSB-BP012903HU CSB-MP012903HU CSB-EP012903HU-B |
Recombinant Human Legumain (LGMN) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP012903HU(A4) | Recombinant Human Legumain(LGMN) | Yeast |
LGMN Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012903RA CSB-EP012903RA CSB-BP012903RA CSB-MP012903RA CSB-EP012903RA-B |
Recombinant Rat Legumain (Lgmn) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LGMN Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012903MOV CSB-BP012903MOV CSB-MP012903MOV CSB-EP012903MOV-B |
Recombinant Macaca fascicularis Legumain (LGMN) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP012903MOV | Recombinant Macaca fascicularis Legumain (LGMN) | E.coli |
| CSB-BP012903MOVb1 | Recombinant Macaca fascicularis Legumain (LGMN) | Baculovirus |
LGMN ELISA Kit
LGMN ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL012903HU | Human Legumain(LGMN) ELISA kit | serum, plasma, tissue homogenates | 15.6 pg/mL |
