LANCL2
LANCL2，即羊毛硫氨酸合成酶C樣蛋白2，別名TASP。它是一種脫落酸受體，表達于人的免疫細胞、上皮細胞和肌肉細胞中，參與應激反應、組織生長、炎癥調節和糖代謝等信號傳遞。LANCL2的作用機制包括與ABA結合，激活信號傳導，增強調節性T細胞（Treg）反應，下調腸道中的效應反應，并參與線粒體代謝和IL-2/CD25信號傳導的免疫調節。LANCL2的藥理學激活在腸道炎癥、系統性紅斑狼瘡、類風濕性關節炎、多發性硬化癥和牛皮癬的小鼠模型中顯示出治療功效。此外，LANCL2還參與了膠質母細胞瘤的侵襲性偽足形成和腫瘤進展，通過激活STAT3/Cortactin信號通路。LANCL2的異常表達與多種疾病的發病機制相關，包括自身免疫性疾病和腫瘤，如膠質母細胞瘤。因此，LANCL2不僅在細胞抗氧化過程中發揮作用，還可能成為未來治療這些疾病的潛在靶點。
熱銷產品
LANCL2 Antibody (CSB-PA865129LA01HU)
驗證數據
Western Blot
Positive WB detected in: A549 whole cell lysate, U87 whole cell lysate
All lanes: LANCL2 antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 51 kDa
Observed band size: 51 kDa
IHC image of CSB-PA865129LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with CSB-PA865129LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
LANCL2 Antibodies
LANCL2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA865129LA01HU | LANCL2 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA865129LB01HU | LANCL2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA865129LC01HU | LANCL2 Antibody, FITC conjugated | Human | |
| CSB-PA865129LD01HU | LANCL2 Antibody, Biotin conjugated | Human | ELISA |
LANCL2 Proteins
LANCL2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP865129HU CSB-EP865129HU CSB-BP865129HU CSB-MP865129HU CSB-EP865129HU-B |
Recombinant Human LanC-like protein 2 (LANCL2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
