KLRD1
KLRD1全稱為殺傷細(xì)胞凝集素樣受體亞家族D成員1，常被稱為CD94抗原或NKG2受體復(fù)合體組成部分。該蛋白主要分布于自然殺傷細(xì)胞（NK細(xì)胞）和部分T細(xì)胞表面，通過(guò)與NKG2家族蛋白（如NKG2A/C）結(jié)合形成異源二聚體，參與識(shí)別細(xì)胞表面的HLA-E分子。這種識(shí)別過(guò)程在免疫監(jiān)視中發(fā)揮關(guān)鍵作用，既能抑制NK細(xì)胞對(duì)正常組織的攻擊，又能激活對(duì)異常細(xì)胞（如病毒感染或癌變細(xì)胞）的殺傷功能。KLRD1表達(dá)水平異常與多種疾病相關(guān)，例如類風(fēng)濕性關(guān)節(jié)炎患者的NK細(xì)胞中CD94表達(dá)顯著升高，而在慢性病毒感染或?qū)嶓w腫瘤微環(huán)境中，受體功能失調(diào)可能導(dǎo)致免疫逃逸。針對(duì)NK細(xì)胞受體的藥物研發(fā)成為熱點(diǎn)，已有抗體藥物通過(guò)阻斷抑制性受體（如NKG2A）來(lái)增強(qiáng)抗腫瘤免疫，相關(guān)療法在頭頸癌、血液腫瘤等領(lǐng)域進(jìn)入臨床試驗(yàn)階段。此外，基于CD94/NKG2調(diào)控機(jī)制的細(xì)胞療法也在探索中，為感染性疾病和癌癥提供新的干預(yù)策略。
熱銷產(chǎn)品
Recombinant Human Natural killer cells antigen CD94 (KLRD1), partial (CSB-MP615672HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KLRD1 Antibody (CSB-PA615672LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA615672LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA615672LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA615672LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
KLRD1 Antibodies
KLRD1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012470GA01HU | KLRD1 Antibody | Human | ELISA,WB |
| CSB-PA615672LA01HU | KLRD1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA615672LC01HU | KLRD1 Antibody, FITC conjugated | Human | |
| CSB-PA615672LD01HU | KLRD1 Antibody, Biotin conjugated | Human | ELISA |
KLRD1 Proteins
KLRD1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012470RA1 CSB-EP012470RA1 CSB-BP012470RA1 CSB-MP012470RA1 CSB-EP012470RA1-B |
Recombinant Rat Natural killer cells antigen CD94 (Klrd1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012470RA | Recombinant Rat Natural killer cells antigen CD94 (Klrd1) | in vitro E.coli expression system |
KLRD1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012470MO1 CSB-EP012470MO1 CSB-BP012470MO1 CSB-MP012470MO1 CSB-EP012470MO1-B |
Recombinant Mouse Natural killer cells antigen CD94 (Klrd1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012470MO | Recombinant Mouse Natural killer cells antigen CD94 (Klrd1) | in vitro E.coli expression system |
KLRD1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP615672HU CSB-EP615672HU CSB-BP615672HU CSB-EP615672HU-B |
Recombinant Human Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP615672HU | Recombinant Human Natural killer cells antigen CD94 (KLRD1), partial | Mammalian cell |
KLRD1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP655045DO CSB-EP655045DO CSB-BP655045DO CSB-MP655045DO CSB-EP655045DO-B |
Recombinant Dog Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRD1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP768113BO CSB-EP768113BO CSB-BP768113BO CSB-MP768113BO CSB-EP768113BO-B |
Recombinant Bovine Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRD1 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP853978EXP CSB-EP853978EXP CSB-BP853978EXP CSB-MP853978EXP CSB-EP853978EXP-B |
Recombinant Pongo pygmaeus Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRD1 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP873550MOW CSB-EP873550MOW CSB-BP873550MOW CSB-MP873550MOW CSB-EP873550MOW-B |
Recombinant Macaca mulatta Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRD1 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP882002EQV CSB-EP882002EQV CSB-BP882002EQV CSB-MP882002EQV CSB-EP882002EQV-B |
Recombinant Pan troglodytes Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
