KLB

KLB（Klotho β），也稱為β-klotho，是一種跨膜蛋白，具有多個(gè)結(jié)構(gòu)域，這些結(jié)構(gòu)域在不同的活性環(huán)境中發(fā)揮著不同的功能。KLB在調(diào)節(jié)礦物質(zhì)代謝、細(xì)胞信號(hào)傳導(dǎo)和衰老過(guò)程中起著重要作用。它與FGF23共同作用，影響磷酸鹽的重吸收和維生素D的活化，同時(shí)可能通過(guò)影響Wnt/β-catenin信號(hào)通路中的β-catenin穩(wěn)定性來(lái)調(diào)節(jié)細(xì)胞增殖和分化。此外，KLB還可能與TGF-β家族成員相互作用，參與調(diào)節(jié)細(xì)胞外基質(zhì)的合成和分解，影響組織修復(fù)和纖維化過(guò)程。KLB的異常表達(dá)或功能失調(diào)與多種疾病相關(guān)，包括慢性腎病、心血管疾病和衰老相關(guān)的疾病，使其成為生物醫(yī)學(xué)研究中的一個(gè)有前景的靶點(diǎn)。

熱銷產(chǎn)品

KLB Antibody (CSB-PA769815LA01HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-PA769815LA01HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA769815LA01HU diluted at 1:200 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA769815LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

KLB Antibody

KLB Protein

KLB ELISA Kit

KLB Antibodies

KLB for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA769815LA01HU	KLB Antibody	Human	ELISA, IHC, IF
CSB-PA769815LB01HU	KLB Antibody, HRP conjugated	Human	ELISA
CSB-PA769815LC01HU	KLB Antibody, FITC conjugated	Human
CSB-PA769815LD01HU	KLB Antibody, Biotin conjugated	Human	ELISA

KLB Proteins

KLB Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP769815HU CSB-EP769815HU CSB-BP769815HU CSB-MP769815HU CSB-EP769815HU-B	Recombinant Human Beta-klotho (KLB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli