KIF11
KIF11（驅(qū)動(dòng)蛋白家族成員11）又稱(chēng)Eg5或Kinesin-5，是一種微管相關(guān)馬達(dá)蛋白，通過(guò)水解ATP產(chǎn)生機(jī)械力推動(dòng)微管滑動(dòng)。它在有絲分裂中驅(qū)動(dòng)雙極紡錘體的形成與分離，確保染色體精確分配到子細(xì)胞，若功能異常可能導(dǎo)致染色體非整倍性，進(jìn)而引發(fā)細(xì)胞癌變或凋亡。該蛋白異常高表達(dá)常見(jiàn)于乳腺癌、結(jié)直腸癌等實(shí)體瘤，與腫瘤增殖、轉(zhuǎn)移及不良預(yù)后相關(guān)。此外，KIF11基因突變可導(dǎo)致常染色體顯性小頭畸形、視網(wǎng)膜變性等罕見(jiàn)神經(jīng)發(fā)育疾病。
針對(duì)KIF11的抗癌藥物研發(fā)聚焦于抑制其ATP酶活性，代表性化合物如ispinesib、filanesib通過(guò)阻斷紡錘體分離迫使癌細(xì)胞停滯在分裂中期。盡管早期臨床試驗(yàn)在血液腫瘤中顯現(xiàn)療效，但實(shí)體瘤響應(yīng)有限且存在神經(jīng)毒性問(wèn)題。近年研究轉(zhuǎn)向聯(lián)合用藥策略，如Eg5抑制劑與紫杉醇聯(lián)用可增強(qiáng)抗微管藥物敏感性。新型變構(gòu)抑制劑ARRY-520已完成II期試驗(yàn)，而PROTAC技術(shù)開(kāi)發(fā)的降解劑正探索克服耐藥性的可能。
熱銷(xiāo)產(chǎn)品
KIF11 Recombinant Monoclonal Antibody (CSB-RA956956A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate, U-251 whole cell lysate, K562 whole cell lysate, HepG2 whole cell lysat
All lanes: Eg5 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 120 kDa
Observed band size: 130 kDa
KIF11 Antibodies
KIF11 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA002261 | KIF11 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA009660 | Phospho-KIF11 (T926) Antibody | Human | WB, ELISA |
| CSB-PA012307LA01HU | KIF11 Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA012307LB01HU | KIF11 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012307LD01HU | KIF11 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA956956A0HU | KIF11 Recombinant Monoclonal Antibody | Human | ELISA, WB |
KIF11 Proteins
KIF11 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP012307HU CSB-EP012307HU CSB-BP012307HU CSB-MP012307HU CSB-EP012307HU-B |
Recombinant Human Kinesin-like protein KIF11 (KIF11), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
