ITGB2

ITGB2全稱為整合素β2亞基，也被稱為CD18或淋巴細(xì)胞功能相關(guān)抗原-1（LFA-1）組成部分。該蛋白主要與α亞基結(jié)合形成異源二聚體，在免疫細(xì)胞表面廣泛表達(dá)，參與白細(xì)胞遷移、炎癥反應(yīng)和免疫應(yīng)答。ITGB2功能異常會導(dǎo)致白細(xì)胞黏附缺陷癥（LAD），患者因免疫細(xì)胞無法有效遷移至感染部位，常出現(xiàn)反復(fù)細(xì)菌感染、傷口愈合困難等癥狀。ITGB2與慢性炎癥性疾病、動脈粥樣硬化及腫瘤轉(zhuǎn)移也存在關(guān)聯(lián)。
在藥物研發(fā)領(lǐng)域，針對ITGB2的靶向策略多聚焦于調(diào)控免疫反應(yīng)。例如LFA-1抑制劑如利妥昔單抗已用于治療類風(fēng)濕性關(guān)節(jié)炎，通過阻斷免疫細(xì)胞過度活化減輕炎癥損傷。新型小分子抑制劑如BMS-986020正在進(jìn)行臨床試驗(yàn)，探索在器官移植排異反應(yīng)中的應(yīng)用。部分研究嘗試?yán)眉{米抗體技術(shù)開發(fā)特異性阻斷劑，但尚未進(jìn)入臨床階段。由于整合素家族成員的功能交叉性，如何實(shí)現(xiàn)精準(zhǔn)靶向仍是當(dāng)前研究的難點(diǎn)。

熱銷產(chǎn)品

ITGB2 Antibody (CSB-PA011884LA01HU)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA011884LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA011884LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

ITGB2 Antibody

ITGB2 Protein

ITGB2 ELISA Kit

ITGB2 Antibodies

ITGB2 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA005838	ITGB2 Antibody	Human	ELISA
CSB-PA011268	Phospho-ITGB2 (T758) Antibody	Human,Mouse,Rat	IF, ELISA
CSB-PA011269	ITGB2 Antibody	Human,Mouse,Rat	IF, ELISA
CSB-PA066585	ITGB2 Antibody	Human,Mouse	ELISA,IHC
CSB-PA877324	ITGB2 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA011884LA01HU	ITGB2 Antibody	Human	ELISA, IHC, IF
CSB-PA011884LB01HU	ITGB2 Antibody, HRP conjugated	Human	ELISA
CSB-PA011884LC01HU	ITGB2 Antibody, FITC conjugated	Human
CSB-PA011884LD01HU	ITGB2 Antibody, Biotin conjugated	Human	ELISA
CSB-RA011884MA1HU	ITGB2 Recombinant Monoclonal Antibody	Human	ELISA, FC

ITGB2 Proteins

ITGB2 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011884MO1 CSB-EP011884MO1 CSB-BP011884MO1 CSB-MP011884MO1 CSB-EP011884MO1-B	Recombinant Mouse Integrin beta-2 (Itgb2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011884MO	Recombinant Mouse Integrin beta-2 (Itgb2)	in vitro E.coli expression system

ITGB2 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011884BO1 CSB-EP011884BO1 CSB-BP011884BO1 CSB-MP011884BO1 CSB-EP011884BO1-B	Recombinant Bovine Integrin beta-2 (ITGB2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011884BO	Recombinant Bovine Integrin beta-2 (ITGB2)	in vitro E.coli expression system

ITGB2 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011884PI1 CSB-EP011884PI1 CSB-BP011884PI1 CSB-MP011884PI1 CSB-EP011884PI1-B	Recombinant Pig Integrin beta-2 (ITGB2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011884PI	Recombinant Pig Integrin beta-2 (ITGB2)	in vitro E.coli expression system

ITGB2 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011884HU1 CSB-EP011884HU1 CSB-BP011884HU1 CSB-MP011884HU1 CSB-EP011884HU1-B	Recombinant Human Integrin beta-2 (ITGB2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011884HU	Recombinant Human Integrin beta-2 (ITGB2)	in vitro E.coli expression system

ITGB2 Proteins for Ovis canadensis (Bighorn sheep)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP651222OAAI CSB-EP651222OAAI CSB-BP651222OAAI CSB-MP651222OAAI CSB-EP651222OAAI-B	Recombinant Ovis canadensis Integrin beta-2 (ITGB2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ITGB2 Proteins for Capra hircus (Goat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP713335GO CSB-EP713335GO CSB-BP713335GO CSB-MP713335GO CSB-EP713335GO-B	Recombinant Goat Integrin beta-2 (ITGB2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ITGB2 Proteins for Ovis aries (Sheep)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP728580SH CSB-EP728580SH CSB-BP728580SH CSB-MP728580SH CSB-EP728580SH-B	Recombinant Sheep Integrin beta-2 (ITGB2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli