ITGA5
整合素α5（ITGA5）是細(xì)胞表面粘附分子家族的重要成員，常與β1亞基結(jié)合形成α5β1異源二聚體受體。ITGA5因能特異性識(shí)別纖維連接蛋白中的RGD序列，被稱作纖維連接蛋白受體，在胚胎發(fā)育、創(chuàng)傷修復(fù)等生理過(guò)程中調(diào)控細(xì)胞粘附與遷移。α5β1通過(guò)激活細(xì)胞內(nèi)FAK/Src信號(hào)網(wǎng)絡(luò)，促進(jìn)腫瘤細(xì)胞侵襲轉(zhuǎn)移能力，其異常表達(dá)與乳腺癌、肝癌、結(jié)直腸癌等惡性腫瘤的進(jìn)展密切相關(guān)。在特發(fā)性肺纖維化、動(dòng)脈粥樣硬化等疾病中，ITGA5也參與異常細(xì)胞外基質(zhì)沉積過(guò)程。目前針對(duì)α5β1的靶向藥物已有十余種進(jìn)入臨床研究，如單抗藥物Volociximab在卵巢癌治療中顯示出抑制血管新生的潛力，小分子抑制劑JSM6427則應(yīng)用于眼底黃斑病變的干預(yù)。由于整合素家族存在功能代償效應(yīng)，部分藥物在臨床試驗(yàn)中出現(xiàn)療效波動(dòng)，如何精準(zhǔn)調(diào)控其活性仍是研發(fā)難點(diǎn)。
熱銷(xiāo)產(chǎn)品
ITGA5 Recombinant Monoclonal Antibody (CSB-RA011868MA1HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA011868MA1HU diluted at 1:50 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
ITGA5 Antibodies
ITGA5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA011868GA01HU | ITGA5 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000070 | Cleaved-ITGA5 (E895) Antibody | Human | WB, ELISA |
| CSB-PA006198 | ITGA5 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA011261 | Cleaved-ITGA5 (F42) Antibody | Human,Mouse | WB, ELISA |
| CSB-PA011868LA01HU | ITGA5 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA011868LB01HU | ITGA5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011868LC01HU | ITGA5 Antibody, FITC conjugated | Human | |
| CSB-PA011868LD01HU | ITGA5 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA011868MA1HU | ITGA5 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
ITGA5 Proteins
ITGA5 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011868MO CSB-EP011868MO CSB-BP011868MO CSB-MP011868MO CSB-EP011868MO-B |
Recombinant Mouse Integrin alpha-5 (Itga5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGA5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011868HU CSB-EP011868HU CSB-BP011868HU CSB-MP011868HU CSB-EP011868HU-B |
Recombinant Human Integrin alpha-5 (ITGA5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP005451HU | Recombinant Human Integrin alpha-5 (ITGA5), partial (Active) | Mammalian cell |
ITGA5 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP630655BO CSB-EP630655BO CSB-BP630655BO CSB-MP630655BO CSB-EP630655BO-B |
Recombinant Bovine Integrin alpha-5 (ITGA5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
