HDAC3
HDAC3，即組蛋白去乙酰化酶3，別名HD3、Histone deacetylase 3、RPD3-2、SMAP45。它是一種由HDAC3基因編碼的酶，屬于I類組蛋白去乙酰化酶家族成員，在多種細(xì)胞類型中廣泛表達(dá)。HDAC3的作用機(jī)制主要是通過(guò)去除組蛋白和非組蛋白上的乙酰基團(tuán)，調(diào)控染色質(zhì)結(jié)構(gòu)和基因表達(dá)，參與細(xì)胞增殖、分化、遷移和凋亡等過(guò)程。HDAC3參與調(diào)節(jié)多種細(xì)胞生命活動(dòng)，包括細(xì)胞周期控制、細(xì)胞應(yīng)激反應(yīng)、代謝調(diào)控等。此外，HDAC3的功能異常與某些疾病有關(guān)，如癌癥、神經(jīng)退行性疾病等，是藥物開(kāi)發(fā)和疾病治療中的潛在靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Histone deacetylase 3 (HDAC3) (CSB-EP010239HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
HDAC3 Recombinant Monoclonal Antibody (CSB-RA906662A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, HL60 whole cell lysate, U251 whole cell lysate, K562 whole cell lysate, 293T whole cell lysate
All lanes: HDAC3 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 49, 50 kDa
Observed band size: 49 kDa
IHC image of CSB-RA906662A0HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA906662A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
HDAC3 Antibodies
HDAC3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010239GA01HU | HDAC3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010239LA01HU | HDAC3 Antibody | Human, Mouse | ELISA, WB, IHC, IF, ChIP |
| CSB-PA010239LB01HU | HDAC3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA916163 | HDAC3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA170084 | Phospho-HDAC3 (Ser424) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA967736 | HDAC3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA002880 | HDAC3 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA004117 | HDAC3 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-PA010572 | Phospho-HDAC3 (S424) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA899967 | HDAC3 Antibody | Human,Rat | ELISA,WB |
| CSB-RA906662A0HU | HDAC3 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
HDAC3 Proteins
HDAC3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010239HU CSB-BP010239HU CSB-MP010239HU CSB-EP010239HU-B |
Recombinant Human Histone deacetylase 3 (HDAC3) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP010239HU | Recombinant Human Histone deacetylase 3 (HDAC3) | E.coli |
