GSDMD
GSDMD，別名GSDMDC1、DFNA5L等。它最初是在小鼠巨噬細(xì)胞中被發(fā)現(xiàn)，是一種新型的細(xì)胞死亡調(diào)節(jié)蛋白，屬于Gasdermin家族。GSDMD的作用機制主要是通過炎癥小體的經(jīng)典或非經(jīng)典途徑被激活，然后在細(xì)胞膜上形成孔洞，導(dǎo)致細(xì)胞炎性死亡，即細(xì)胞焦亡。在細(xì)胞焦亡過程中，GSDMD被炎性caspase剪切，釋放出活性氨基末端片段（GSDMD-NT），該片段轉(zhuǎn)移到細(xì)胞質(zhì)膜上并發(fā)生構(gòu)象變化及寡聚，形成插膜的孔狀結(jié)構(gòu)，導(dǎo)致細(xì)胞內(nèi)容物釋放和炎癥反應(yīng)。GSDMD在宿主抵抗病原體免疫中發(fā)揮著重要作用，其介導(dǎo)的細(xì)胞焦亡與多種疾病的發(fā)生發(fā)展密切相關(guān)，包括心血管疾病、傳染性疾病、腫瘤及自身免疫性疾病等，具有重要的生物學(xué)意義。
熱銷產(chǎn)品
Recombinant Human Gasdermin-D (GSDMD) (CSB-EP009956HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
GSDMD Antibodies
GSDMD for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009956GA01HU | GSDMD Antibody | Human | ELISA,WB,IF |
| CSB-PA009956LA01HU | GSDMD Antibody | Human | ELISA, WB |
| CSB-PA009956LD01HU | GSDMD Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA009956LC01HU | GSDMD Antibody, FITC conjugated | Human | |
| CSB-PA009956LB01HU | GSDMD Antibody, HRP conjugated | Human | ELISA |
GSDMD Proteins
GSDMD Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009956HU CSB-BP009956HU CSB-MP009956HU |
Recombinant Human Gasdermin-D (GSDMD) | Yeast Baculovirus Mammalian cell |
| CSB-EP009956HU | Recombinant Human Gasdermin-D (GSDMD) | E.coli |
| CSB-EP009956HU-B | Recombinant Human Gasdermin-D (GSDMD),Biotinylated | E.coli |
| CSB-EP009956HUc7 | Recombinant Human Gasdermin-D (GSDMD) | E.coli |
GSDMD Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP866713MO1 CSB-BP866713MO1 CSB-MP866713MO1 CSB-EP866713MO1-B |
Recombinant Mouse Gasdermin-D (Gsdmd), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP866713MO1 | Recombinant Mouse Gasdermin-D (Gsdmd), partial | E.coli |
