GABPA

GABPA，即轉錄因子GABPA，別名GA結合蛋白α亞單位。它是一種由GABPA基因編碼的轉錄因子，屬于基本區域-亮氨酸拉鏈(basic region-leucine zipper, bZip)轉錄因子家族成員。GABPA在多種細胞類型中都有表達，并且在細胞對生長因子和神經遞質的響應中發揮重要作用。GABPA的作用機制主要是通過識別并結合到DNA上的特定序列，即GA結合位點(GA box)，調控下游基因的轉錄。GABPA能夠形成同源二聚體或與其他bZip家族成員形成異源二聚體，進而增強或抑制特定基因的表達。此外，GABPA的活性受到多種信號通路的調控，包括cAMP/PKA、MAPK/ERK和PI3K/Akt等。在生物學意義上，GABPA參與了多種細胞生命活動的調控，包括細胞增殖、分化、代謝和凋亡等。GABPA的功能異常與多種疾病有關，尤其是與神經系統疾病和腫瘤的發生發展密切相關。例如，在神經發育過程中，GABPA通過調控神經相關基因的表達，影響神經元的分化和突觸的形成。在腫瘤細胞中，GABPA的異常表達可能促進腫瘤細胞的增殖和侵襲，使其成為腫瘤治療的潛在靶點。因此，GABPA是細胞生物學和疾病研究中的一個重要轉錄因子。

熱銷產品

Recombinant Mouse GA-binding protein alpha chain (Gabpa) (CSB-EP4582MO)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GABPA Antibody (CSB-PA22769A0Rb)

驗證數據

IHC image of CSB-PA22769A0Rb diluted at 1:200 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA22769A0Rb diluted at 1:200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA22769A0Rb at 1:67, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

GABPA Antibody

GABPA Antibodies

GABPA for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA22769A0Rb	GABPA Antibody	Human	ELISA, IHC, IF
CSB-PA22769B0Rb	GABPA Antibody, HRP conjugated	Human	ELISA
CSB-PA22769D0Rb	GABPA Antibody, Biotin conjugated	Human	ELISA