FZD4
Frizzled-4 is a protein in humans that is encoded by FZD4 gene. Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
FZD4 Antibodies
FZD4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA060235 | FZD4 Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA060236 | FZD4 Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA913541 | FZD4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA362762 | FZD4 Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA890755LA01HU | FZD4 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA890755LB01HU | FZD4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA890755LC01HU | FZD4 Antibody, FITC conjugated | Human | |
| CSB-PA890755LD01HU | FZD4 Antibody, Biotin conjugated | Human | ELISA |
FZD4 Proteins
FZD4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP733770MO1 CSB-EP733770MO1 CSB-BP733770MO1 CSB-MP733770MO1 CSB-EP733770MO1-B |
Recombinant Mouse Frizzled-4 (Fzd4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF733770MO | Recombinant Mouse Frizzled-4 (Fzd4) | in vitro E.coli expression system |
FZD4 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP862309CH1 CSB-EP862309CH1 CSB-BP862309CH1 CSB-MP862309CH1 CSB-EP862309CH1-B |
Recombinant Chicken Frizzled-4 (FZD4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF862309CH | Recombinant Chicken Frizzled-4 (FZD4) | in vitro E.coli expression system |
FZD4 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP865610RA1 CSB-EP865610RA1 CSB-BP865610RA1 CSB-MP865610RA1 CSB-EP865610RA1-B |
Recombinant Rat Frizzled-4 (Fzd4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF865610RA | Recombinant Rat Frizzled-4 (Fzd4) | in vitro E.coli expression system |
FZD4 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP874031XBE1 CSB-EP874031XBE1 CSB-BP874031XBE1 CSB-MP874031XBE1 CSB-EP874031XBE1-B |
Recombinant Xenopus laevis Frizzled-4 (fzd4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF874031XBE | Recombinant Xenopus laevis Frizzled-4 (fzd4) | in vitro E.coli expression system |
FZD4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP890755HU1 CSB-EP890755HU1 CSB-BP890755HU1 CSB-MP890755HU1 CSB-EP890755HU1-B |
Recombinant Human Frizzled-4 (FZD4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF890755HU | Recombinant Human Frizzled-4 (FZD4) | in vitro E.coli expression system |
