FOXM1
FOXM1，全稱為叉頭框蛋白M1，是一種與細(xì)胞周期調(diào)控密切相關(guān)的轉(zhuǎn)錄因子蛋白。該蛋白在多種癌癥中過表達(dá)，如肺癌、肝癌、乳腺癌、腦癌等，是癌癥發(fā)生和發(fā)展的關(guān)鍵驅(qū)動(dòng)因素。FOXM1的常見別名包括FKHL16、FOXM1B、HFH-11、HFH11、HNF-3、INS-1、MPHOSPH2、MPP-2、MPP2、PIG29、TGT3和TRIDENT。FOXM1在正常成人胸腺和睪丸中高表達(dá)，在肺和腸道中中度表達(dá)。研究表明，F(xiàn)OXM1的異常上調(diào)會(huì)導(dǎo)致細(xì)胞基因組不穩(wěn)定，進(jìn)而引發(fā)癌癥病變。FOXM1的表達(dá)成為癌癥測試和預(yù)防藥物開發(fā)的重點(diǎn)。目前，針對(duì)FOXM1的靶向治療研究主要集中在RNA干擾和特異性抑制劑等方面，但多集中在細(xì)胞層面，尚未有動(dòng)物體內(nèi)試驗(yàn)和人體試驗(yàn)。FOXM1有望成為胰腺癌診斷、評(píng)估治療及預(yù)后的重要指標(biāo)，并成為治療胰腺癌的新靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Forkhead box protein M1 (FOxM1), partial (CSB-EP008828HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FOXM1 Antibody (CSB-PA008828HA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA008828HA01HU at dilution of 1:100
FOXM1 Antibodies
FOXM1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA008828GA01HU | FOXM1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA008828HA01HU | FOXM1 Antibody | Human | ELISA, IHC |
| CSB-PA008828HB01HU | FOXM1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008828HC01HU | FOXM1 Antibody, FITC conjugated | Human | |
| CSB-PA008828HD01HU | FOXM1 Antibody, Biotin conjugated | Human | ELISA |
FOXM1 Proteins
FOXM1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008828RA CSB-EP008828RA CSB-BP008828RA CSB-MP008828RA CSB-EP008828RA-B |
Recombinant Rat Forkhead box protein M1 (Foxm1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOXM1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008828MO CSB-EP008828MO CSB-BP008828MO CSB-MP008828MO CSB-EP008828MO-B |
Recombinant Mouse Forkhead box protein M1 (Foxm1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOXM1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP716588XBE CSB-EP716588XBE CSB-BP716588XBE CSB-MP716588XBE CSB-EP716588XBE-B |
Recombinant Xenopus laevis Forkhead box protein M1 (foxm1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOXM1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP008828HU | Recombinant Human Forkhead box protein M1 (FOxM1), partial | E.coli |
| CSB-EP008828HU1 | Recombinant Human Forkhead box protein M1 (FOxM1), partial | E.coli |
