FKBP1A
FKBP1A，即FKBP脯氨酸異構(gòu)酶1A，別名FKBP12。它是一種在細胞內(nèi)具有多種生物學(xué)功能的蛋白質(zhì)，由人體細胞自身的基因編碼。FKBP1A的作用機制涉及到其作為順式/反式肽基脯氨酰異構(gòu)酶(cis/trans peptidyl prolyl isomerase, PPIase)的活性，這種酶能夠催化蛋白質(zhì)肽鏈中脯氨酸殘基的順式和反式構(gòu)象的相互轉(zhuǎn)換，從而參與蛋白質(zhì)的折疊和穩(wěn)定性調(diào)節(jié)。FKBP1A還參與調(diào)節(jié)包括mTOR/AKT信號通路在內(nèi)的多種信號傳導(dǎo)途徑。FKBP1A在生物學(xué)上的意義主要體現(xiàn)在其參與調(diào)節(jié)的多種細胞生理過程，包括細胞增殖、代謝、免疫反應(yīng)等。在腫瘤生物學(xué)中，F(xiàn)KBP1A被發(fā)現(xiàn)在多種癌癥中表達上調(diào)，并與腫瘤的惡性行為相關(guān)。例如，在胃癌中，F(xiàn)KBP1A的高表達與患者的不良預(yù)后相關(guān)，并且可能通過激活PI3K/AKT信號通路來促進癌細胞的糖代謝和惡性生物學(xué)行為。此外，F(xiàn)KBP1A還涉及炎癥相關(guān)信號通路的調(diào)節(jié)，對炎癥、適應(yīng)性免疫反應(yīng)、癌癥和發(fā)育生物學(xué)等過程具有重要作用。
熱銷產(chǎn)品
Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A), partial (CSB-EP008691HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FKBP1A Antibody (CSB-PA02325A0Rb)
驗證數(shù)據(jù)
Western blot
All lanes: FKBP1A antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 12 kDa
Observed band size: 12 kDa
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA02325A0Rb at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA02325A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
FKBP1A Antibodies
FKBP1A for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA02325A0Rb | FKBP1A Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA02325B0Rb | FKBP1A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA02325D0Rb | FKBP1A Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA008691GA01HU | FKBP1A Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
FKBP1A Proteins
FKBP1A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008691HU CSB-EP008691HU CSB-BP008691HU CSB-MP008691HU CSB-EP008691HU-B |
Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP008691HU1 | Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A), partial | E.coli |
