FGFR1
FGFR1，即成纖維細(xì)胞生長(zhǎng)因子受體1，它是一種膜結(jié)合蛋白，由FGFR1基因編碼。FGFR1廣泛存在于多種組織中，是成纖維細(xì)胞生長(zhǎng)因子(FGF)家族的高親和力受體。其作用機(jī)制是FGF與其結(jié)合后，F(xiàn)GFR1發(fā)生二聚化或寡聚化，激活其內(nèi)在的酪氨酸激酶活性，進(jìn)而觸發(fā)下游的信號(hào)傳導(dǎo)途徑，如RAS/MAPK、PI3K/AKT等。這些信號(hào)通路參與調(diào)節(jié)細(xì)胞的增殖、分化、遷移和存活。FGFR1的生物學(xué)意義在于其在胚胎發(fā)育、組織修復(fù)、血管生成和腫瘤發(fā)生等過(guò)程中的重要作用。FGFR1的異常激活與多種癌癥的發(fā)生發(fā)展密切相關(guān)，因此，F(xiàn)GFR1也是腫瘤治療的潛在靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human Fibroblast growth factor receptor 1 (FGFR1), partial (CSB-YP008642HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FGFR1 Recombinant Monoclonal Antibody (CSB-RA008642MA1HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA008642MA1HU diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Rabbit IgG labeled by HRP and visualized using 0.05% DAB.
Immunofluorescence staining of Hela cell with CSB-RA008642MA1HU at 1:20, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Overlay Peak curve showing MCF7 cells stained with CSB-RA008642MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Rabbit IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was rabbit IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,026 events was performed.
FGFR1 Antibodies
FGFR1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA178976 | FGFR1 (Ab-721) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA097377 | Phospho-FGFR1 (Tyr654) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA138978 | Phospho-FGFR1 (Tyr766) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA273913 | FGFR1 (Ab-766) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000662 | Phospho-FGFR1 (Y154) Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA002537 | FGFR1 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA002538 | FGFR1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA008243 | Phospho-FGFR1 (Y654) Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA008244 | Phospho-FGFR1 (Y766) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA008245 | FGFR1 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA086441 | FGFR1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA008642LA01HU | FGFR1 Antibody | Human | ELISA, WB, IF |
| CSB-PA008642LB01HU | FGFR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008642LC01HU | FGFR1 Antibody, FITC conjugated | Human | |
| CSB-PA008642LD01HU | FGFR1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA008642MA1HU | FGFR1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF, FC |
FGFR1 Proteins
FGFR1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP008642RA CSB-EP008642RA CSB-BP008642RA CSB-MP008642RA CSB-EP008642RA-B |
Recombinant Rat Fibroblast growth factor receptor 1 (Fgfr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-EP008642HU CSB-BP008642HU CSB-MP008642HU CSB-EP008642HU-B |
Recombinant Human Fibroblast growth factor receptor 1 (FGFR1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP008642HUa0 | Recombinant Human Fibroblast growth factor receptor 1 (FGFR1), partial | E.coli |
| CSB-YP008642HUa4 | Recombinant Human Fibroblast growth factor receptor 1 (FGFR1), partial | Yeast |
| CSB-EP008642HU1 | Recombinant Human Fibroblast growth factor receptor 1 (FGFR1), partial | E.coli |
| CSB-YP008642HU | Recombinant Human Fibroblast growth factor receptor 1 (FGFR1), partial | Yeast |
| CSB-MP008642HUc7 | Recombinant Human Fibroblast growth factor receptor 1 (FGFR1), partial | Mammalian cell |
FGFR1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP008642CH1 CSB-EP008642CH1 CSB-BP008642CH1 CSB-MP008642CH1 CSB-EP008642CH1-B |
Recombinant Chicken Fibroblast growth factor receptor 1 (FGFR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008642CH | Recombinant Chicken Fibroblast growth factor receptor 1 (FGFR1) | in vitro E.coli expression system |
FGFR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP008642MO CSB-EP008642MO CSB-BP008642MO CSB-MP008642MO CSB-EP008642MO-B |
Recombinant Mouse Fibroblast growth factor receptor 1 (Fgfr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP008642XBE1 CSB-EP008642XBE1 CSB-BP008642XBE1 CSB-MP008642XBE1 CSB-EP008642XBE1-B |
Recombinant Xenopus laevis Fibroblast growth factor receptor 1 (fgfr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008642XBE | Recombinant Xenopus laevis Fibroblast growth factor receptor 1 (fgfr1) | in vitro E.coli expression system |
FGFR1 Proteins for Pleurodeles waltl (Iberian ribbed newt)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP008642EWZ CSB-EP008642EWZ CSB-BP008642EWZ CSB-MP008642EWZ CSB-EP008642EWZ-B |
Recombinant Pleurodeles waltl Fibroblast growth factor receptor 1 (FGFR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR1 Proteins for Dugesia japonica (Planarian)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP008642DMU CSB-EP008642DMU CSB-BP008642DMU CSB-MP008642DMU CSB-EP008642DMU-B |
Recombinant Dugesia japonica Fibroblast growth factor receptor 1 (FGFR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
