FGF19
FGF19，全稱為成纖維細(xì)胞生長因子19，是一種重要的蛋白質(zhì)，在人體生長發(fā)育、新陳代謝以及組織穩(wěn)態(tài)中發(fā)揮著關(guān)鍵作用。FGF19也被稱為FGF-19或Fibroblast growth factor 19。該蛋白主要在胎兒腦組織中表達(dá)，參與器官發(fā)生過程，影響耳、眼、心、腦等器官的發(fā)育。FGF19通過與FGFR4結(jié)合，調(diào)節(jié)肝細(xì)胞的膽汁酸代謝和損傷后的肝再生，其異常活化與肝細(xì)胞癌（HCC）的發(fā)生發(fā)展密切相關(guān)。FGF19在多種代謝性疾病中也發(fā)揮作用，如原發(fā)性硬化性膽管炎和代謝綜合征相關(guān)性脂肪性肝炎。目前，基于FGF19的藥物研發(fā)已取得顯著進(jìn)展，例如和譽(yù)醫(yī)藥研發(fā)的FGFR4抑制劑ABSK011，在治療FGF19過表達(dá)的晚期肝細(xì)胞癌中展現(xiàn)出優(yōu)異的療效和安全性。此外，F(xiàn)GF19也被用作糖尿病、肥胖和腫瘤導(dǎo)致的代謝紊亂等相關(guān)疾病的臨床診斷生物標(biāo)志物。FGF19的研究為代謝性疾病的治療提供了新的思路和方向，未來有望為更多患者帶來新的治療選擇。
熱銷產(chǎn)品
FGF19 Recombinant Monoclonal Antibody (CSB-RA546047A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Ntera-2 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: FGF19 antibody at 1:500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 25 kDa
Observed band size: 36 kDa
Human Fibroblast growth factor 19(FGF19) ELISA kit (CSB-EL008624HU)
驗(yàn)證數(shù)據(jù)
貨號：CSB-EL008624HU
規(guī)格：96T/48T
靈敏度：6.25 pg/mL
檢測范圍：25 pg/mL-1600 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
FGF19 Antibodies
FGF19 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA008624ESR1HU | FGF19 Antibody | Human | ELISA, IHC |
| CSB-PA008624ESR2HU | FGF19 Antibody | Human | ELISA, WB |
| CSB-PA008624EA01HU | FGF19 Antibody | Human | ELISA, WB, IHC |
| CSB-PA008624ED01HU | FGF19 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA008624EC01HU | FGF19 Antibody, FITC conjugated | Human | |
| CSB-PA008624EB01HU | FGF19 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA546047A0HU | FGF19 Recombinant Monoclonal Antibody | Human | ELISA, WB |
FGF19 Proteins
FGF19 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008624HU CSB-EP008624HU CSB-BP008624HU CSB-MP008624HU CSB-EP008624HU-B |
Recombinant Human Fibroblast growth factor 19 (FGF19) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP063944h | Recombinant Human Fibroblast growth factor 19 protein (FGF-19) , partial | E.coli |
| CSB-AP002461HU | Recombinant Human Fibroblast growth factor 19 (FGF19), partial (Active) | E.Coli |
FGF19 ELISA Kit
FGF19 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL008624HU | Human Fibroblast growth factor 19(FGF19) ELISA kit | serum, plasma, tissue homogenates | 6.25 pg/mL |
