EPHA2
EphA2,全稱為Erythropoietin-producing hepatocellular A2,是一種關(guān)鍵的受體酪氨酸激酶。它參與細(xì)胞信號轉(zhuǎn)導(dǎo)、細(xì)胞間相互作用以及組織發(fā)育等多種生物學(xué)過程。EphA2蛋白在胚胎發(fā)育中發(fā)揮重要作用,如調(diào)節(jié)血管生成、后腦發(fā)育和乳腺形態(tài)發(fā)生等。此外,它還與丙型肝炎病毒的感染機(jī)制相關(guān),作為病毒受體促進(jìn)病毒進(jìn)入細(xì)胞。
近年來,EphA2蛋白在癌癥發(fā)生和發(fā)展中的作用逐漸被揭示。研究發(fā)現(xiàn),EphA2蛋白在癌癥中具有雙重角色:一方面,它可以抑制癌癥的生長和擴(kuò)散;另一方面,經(jīng)過某些腫瘤相關(guān)蛋白修飾后,EphA2可能促進(jìn)癌癥的發(fā)生。這種復(fù)雜性使得EphA2成為癌癥治療研究的重要靶點(diǎn)。目前,針對EphA2的靶向治療藥物正在研發(fā)中,有望為癌癥患者提供新的治療策略。
熱銷產(chǎn)品
Recombinant Human Ephrin type-A receptor 2 (EPHA2F), partial (Active) (CSB-MP007722HUd7)
驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 2 μg/ml can bind Anti-EPHA2 recombinant antibody (CSB-RA007722MA1HU). The EC50 is 36.24-50.53 ng/mL.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 2 μg/ml can bind Human EFNA1 (CSB-MP007460HU). The EC50 is 5.859-7.758 ng/mL.

The purity of EPHA2F was greater than 95% as determined by SEC-HPLC
EPHA2 Antibody (CSB-PA007722LA01HU)
驗(yàn)證數(shù)據(jù)

IHC image of CSB-PA007722LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA007722LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human Ephrin type-A receptor 2(EPHA2) ELISA kit (CSB-EL007722HU)
驗(yàn)證數(shù)據(jù)

貨號:CSB-EL007722HU
規(guī)格:96T/48T
靈敏度:0.039 ng/mL
檢測范圍:0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
EPHA2 Antibodies
EPHA2 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA007722GA01HU | EPHA2 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA282887 | EPHA2 Antibody | Human | ELISA,WB |
CSB-PA000520 | Phospho-EPHA2 (Y588) Antibody | Human,Mouse | WB, ELISA |
CSB-PA007983 | EPHA2 Antibody | Human,Mouse | WB, ELISA |
CSB-PA179150 | EPHA2 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA007722LA01HU | EPHA2 Antibody | Human | ELISA, IHC, IF |
CSB-PA007722LB01HU | EPHA2 Antibody, HRP conjugated | Human | ELISA |
CSB-PA007722LC01HU | EPHA2 Antibody, FITC conjugated | Human | |
CSB-PA007722LD01HU | EPHA2 Antibody, Biotin conjugated | Human | ELISA |
EPHA2 Proteins
EPHA2 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP007722HU CSB-EP007722HU CSB-BP007722HU CSB-EP007722HU-B |
Recombinant Human Ephrin type-A receptor 2 (EPHA2), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP007722HU | Recombinant Human Ephrin type-A receptor 2 (EPHA2), partial | Mammalian cell |
CSB-EP007722HU1 | Recombinant Human Ephrin type-A receptor 2 (EPHA2), partial | E.coli |
CSB-AP005591HU | Recombinant Human Ephrin type-A receptor 2 (EPHA2), partial (Active) | Mammalian cell |
CSB-MP007722HUd7 | Recombinant Human Ephrin type-A receptor 2 (EPHA2F), partial (Active) | Mammalian cell |
EPHA2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP628848MOV CSB-EP628848MOV CSB-BP628848MOV CSB-MP628848MOV CSB-EP628848MOV-B |
Recombinant Macaca fascicularis Ephrin type-A receptor 2 (EPHA2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPHA2 ELISA Kit
EPHA2 ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-EL007722HU | Human Ephrin type-A receptor 2(EPHA2) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.039 ng/mL |