DPYSL2
DPYSL2，全稱為Dihydropyrimidinase-related protein 2，常見(jiàn)別名包括DRP-2、CRMP-2等。該蛋白在神經(jīng)元發(fā)育、極性、軸突生長(zhǎng)、引導(dǎo)、生長(zhǎng)錐塌陷和細(xì)胞遷移中發(fā)揮著至關(guān)重要的作用，與3類信號(hào)蛋白和鈣通道相互作用，參與神經(jīng)元生長(zhǎng)和突觸可塑性的調(diào)控。DPYSL2蛋白的異常表達(dá)或功能異常與多種神經(jīng)系統(tǒng)疾病相關(guān)，如阿爾茨海默病、帕金森病等。目前，針對(duì)DPYSL2蛋白的藥物研發(fā)尚處于早期階段，但已有研究表明，靶向DPYSL2蛋白的藥物可能為治療阿爾茨海默病等神經(jīng)系統(tǒng)疾病提供新的治療策略。
熱銷產(chǎn)品
Recombinant Human Dihydropyrimidinase-related protein 2 (DPYSL2) (CSB-YP614975HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP614975HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) DPYSL2.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP614975HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) DPYSL2.
DPYSL2 Recombinant Monoclonal Antibody (CSB-RA029079A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA029079A0HU diluted at 1:50 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.35% DAB.
Immunofluorescence staining of SH-SY5Y with CSB-RA029079A0HU at 1:25, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 506-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Overlay Peak curve showing SH-SY5Y cells stained with CSB-RA029079A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
DPYSL2 Antibodies
DPYSL2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007170GA01HU | DPYSL2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA240818 | Phospho-DPYSL2 (Thr514) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA196916 | Phospho-DPYSL2 (Thr509) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA088532 | Phospho-DPYSL2 (Ser522) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA140800 | DPYSL2 (Ab-509) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA982099 | DPYSL2 (Ab-522) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA007819 | Phospho-DPYSL2 (S522) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007820 | Phospho-DPYSL2 (T509) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007821 | Phospho-DPYSL2 (T514) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA007822 | DPYSL2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007824 | DPYSL2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA007828 | DPYSL2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA950736 | DPYSL2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA614975YA01HU | DPYSL2 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA614975YB01HU | DPYSL2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA614975YC01HU | DPYSL2 Antibody, FITC conjugated | Human | |
| CSB-PA614975YD01HU | DPYSL2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA029079A0HU | DPYSL2 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF, FC |
| CSB-RA614975MA1HU | DPYSL2 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
DPYSL2 Proteins
DPYSL2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP614975HU | Recombinant Human Dihydropyrimidinase-related protein 2 (DPYSL2) | Yeast |
| CSB-EP614975HU CSB-BP614975HU CSB-MP614975HU CSB-EP614975HU-B |
Recombinant Human Dihydropyrimidinase-related protein 2 (DPYSL2) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
