CXCR1
CXCR1對應的蛋白全稱為C-X-C趨化因子受體1型，也被稱為IL8RA或CD128a。該蛋白主要存在于中性粒細胞表面，能夠特異性結合白細胞介素-8（IL-8）等趨化因子，在炎癥反應和免疫調節(jié)中發(fā)揮關鍵作用。當機體受到感染或損傷時，CXCR1通過傳遞化學信號引導免疫細胞定向遷移至病灶區(qū)域，同時激活炎癥介質的釋放，參與清除病原體的過程。CXCR1的異常表達與慢性呼吸道疾病、自身免疫性疾病密切相關，其在腫瘤微環(huán)境中的促炎特性還可能加速癌細胞擴散。近年來，針對該蛋白的藥物開發(fā)聚焦于抑制過度活躍的炎癥反應，例如小分子拮抗劑Reparixin已進入乳腺癌和胰腺癌的臨床試驗階段，但存在靶點選擇性不足的局限性。此外，部分研究嘗試通過阻斷CXCR1與IL-8的相互作用來延緩肺纖維化進展，為相關疾病的精準治療提供了新方向。
熱銷產品
驗證數據
Immunohistochemical analysis of paraffin-embedded Human-liver-cancer, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded Human-liver-cancer, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded Human-placenta, antibody was diluted at 1:100
CXCR1 Antibodies
CXCR1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA239685 | CXCR1 Antibody | Human | ELISA,WB |
| CSB-PA821914 | CXCR1 Antibody | Human | IHC,ELISA |
CXCR1 Proteins
CXCR1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011672HU1 CSB-EP011672HU1 CSB-BP011672HU1 CSB-MP011672HU1 CSB-EP011672HU1-B |
Recombinant Human C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011672HU | Recombinant Human C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP304062RA1 CSB-EP304062RA1 CSB-BP304062RA1 CSB-MP304062RA1 CSB-EP304062RA1-B |
Recombinant Rat C-X-C chemokine receptor type 1 (Cxcr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF304062RA | Recombinant Rat C-X-C chemokine receptor type 1 (Cxcr1) | in vitro E.coli expression system |
CXCR1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP325015RB1 CSB-EP325015RB1 CSB-BP325015RB1 CSB-MP325015RB1 CSB-EP325015RB1-B |
Recombinant Rabbit C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF325015RB | Recombinant Rabbit C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP345524GGZ1 CSB-EP345524GGZ1 CSB-BP345524GGZ1 CSB-MP345524GGZ1 CSB-EP345524GGZ1-B |
Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF345524GGZ | Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP345918EQV1 CSB-EP345918EQV1 CSB-BP345918EQV1 CSB-MP345918EQV1 CSB-EP345918EQV1-B |
Recombinant Pan troglodytes C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF345918EQV | Recombinant Pan troglodytes C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Bunopithecus hoolock (Hoolock gibbon) (Hoolock hoolock)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP647407BXO1 CSB-EP647407BXO1 CSB-BP647407BXO1 CSB-MP647407BXO1 CSB-EP647407BXO1-B |
Recombinant Bunopithecus hoolock C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF647407BXO | Recombinant Bunopithecus hoolock C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP648994EXP1 CSB-EP648994EXP1 CSB-BP648994EXP1 CSB-MP648994EXP1 CSB-EP648994EXP1-B |
Recombinant Pongo pygmaeus C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF648994EXP | Recombinant Pongo pygmaeus C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP652126MOW1 CSB-EP652126MOW1 CSB-BP652126MOW1 CSB-MP652126MOW1 CSB-EP652126MOW1-B |
Recombinant Macaca mulatta C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF652126MOW | Recombinant Macaca mulatta C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP800386MO1 CSB-EP800386MO1 CSB-BP800386MO1 CSB-MP800386MO1 CSB-EP800386MO1-B |
Recombinant Mouse C-X-C chemokine receptor type 1 (Cxcr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF800386MO | Recombinant Mouse C-X-C chemokine receptor type 1 (Cxcr1) | in vitro E.coli expression system |
