COL18A1
COL18A1，作為膠原蛋白家族的重要成員，具有獨特的分子結構，通過其特定的氨基酸序列在細胞外基質中發(fā)揮關鍵作用。在功能上，COL18A1不僅參與視網(wǎng)膜的形成和維持，確保視網(wǎng)膜正常功能，還調節(jié)內皮細胞的遷移、增殖和粘附等過程，對血管生成、傷口愈合以及胎盤循環(huán)建立至關重要。同時，COL18A1能夠特異性地抑制內皮細胞增殖和血管生成，通過抑制內皮細胞遷移和粘附，下調血管生成相關基因表達來實現(xiàn)。在信號通路上，COL18A1通過與內皮細胞表面受體結合，觸發(fā)一系列細胞內信號轉導，涉及轉谷氨酰胺酶2、肝素、整合素α5 beta 1和αV beta 3等分子的相互作用，導致細胞骨架重排、基因表達改變以及細胞行為調整。此外，COL18A1的突變與某些疾病如諾布洛赫綜合征相關，突顯其在維持正常生理功能和預防疾病中的重要作用。盡管我們對COL18A1已有一定了解，但仍需進一步探索其未知領域，以揭示其在生理和病理過程中的更多作用，并為新治療策略的開發(fā)提供線索。
熱銷產(chǎn)品
Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP005725HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) COL18A1.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP005725HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) COL18A1.
COL18A1 Antibodies
COL18A1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005725GA01HU | COL18A1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA044575 | COL18A1 Antibody | Human | ELISA,IHC |
| CSB-PA057835 | COL18A1 Antibody | Human,Mouse | ELISA,IHC,IF |
| CSB-PA060191 | COL18A1 Antibody | Human,Mouse | IHC, IF, ELISA |
| CSB-PA010559 | COL18A1 Antibody | Human,Mouse | IHC, ELISA |
| CSB-PA199023 | COL18A1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA005725LA01HU | COL18A1 Antibody | Human | ELISA, IF |
| CSB-PA005725LB01HU | COL18A1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA005725LC01HU | COL18A1 Antibody, FITC conjugated | Human | |
| CSB-PA005725LD01HU | COL18A1 Antibody, Biotin conjugated | Human | ELISA |
COL18A1 Proteins
COL18A1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005725HU | Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial | Yeast |
| CSB-EP005725HU | Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial | E.coli |
| CSB-BP005725HU CSB-MP005725HU CSB-EP005725HU-B |
Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP005725HU4c7 | Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial | Yeast |
| CSB-YP005725HU4 | Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial | Yeast |
