CHRNA4
CHRNA4全稱為神經(jīng)元煙堿型乙酰膽堿受體的α4亞基，常被稱為nAChR α4或CHRN4。這類受體廣泛分布于中樞神經(jīng)系統(tǒng)，尤其在丘腦和前額葉皮層中富集，通過(guò)結(jié)合乙酰膽堿參與神經(jīng)信號(hào)的傳遞，調(diào)控注意力、記憶及覺醒狀態(tài)。CHRNA4功能異常與多種神經(jīng)系統(tǒng)疾病密切相關(guān)，例如某些家族性夜間額葉癲癇患者的突變位點(diǎn)常出現(xiàn)在該基因區(qū)域，導(dǎo)致神經(jīng)元興奮性失衡。此外，該受體還涉及尼古丁成癮機(jī)制，吸煙者體內(nèi)長(zhǎng)期尼古丁刺激可能引發(fā)受體脫敏，形成依賴性。帕金森病、阿爾茨海默病等神經(jīng)退行性疾病中也觀察到該受體表達(dá)水平的變化。近年來(lái)，針對(duì)α4亞基的藥物研究集中在精神類疾病和戒斷治療領(lǐng)域，例如部分抗癲癇藥物通過(guò)增強(qiáng)受體功能緩解癥狀，而伐尼克蘭等戒煙藥物則通過(guò)部分激活受體降低尼古丁渴求。不過(guò)，由于該受體在中樞的多重調(diào)控作用，藥物研發(fā)需平衡療效與副作用風(fēng)險(xiǎn)，目前尚無(wú)雙靶點(diǎn)特異性藥物進(jìn)入臨床后期階段。
熱銷產(chǎn)品
CHRNA4 Antibody (CSB-PA215866)
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA215866(CHRNA4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA215866(CHRNA4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lovo cells, 293T cells, Primary antibody: CSB-PA215866(CHRNA4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
CHRNA4 Antibodies
CHRNA4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA938221 | CHRNA4 Antibody | Human | ELISA,IHC |
| CSB-PA215866 | CHRNA4 Antibody | Human | ELISA,WB,IHC |
CHRNA4 Proteins
CHRNA4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP005390HU CSB-EP005390HU CSB-BP005390HU CSB-MP005390HU CSB-EP005390HU-B |
Recombinant Human Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
