CDH5
CDH5，即血管內(nèi)皮鈣粘蛋白，別名VE-cadherin/Cadherin-5。它是一種由CDH5基因編碼的II型經(jīng)典鈣粘蛋白家族成員，主要在血管內(nèi)皮細(xì)胞中表達(dá)。CDH5的作用機(jī)制涉及介導(dǎo)內(nèi)皮細(xì)胞間的同質(zhì)性粘附，通過(guò)其細(xì)胞外結(jié)構(gòu)域與相鄰細(xì)胞的CDH5分子相互作用，形成穩(wěn)定的粘附連接。這種粘附對(duì)于維持血管完整性和調(diào)節(jié)血管通透性至關(guān)重要。此外，CDH5與α-連環(huán)蛋白結(jié)合，形成與細(xì)胞骨架的連接，參與調(diào)控內(nèi)皮細(xì)胞的極性和血管腔的形成。CDH5的功能還涉及到與KRIT1和PAR-1等蛋白的相互作用，共同維持內(nèi)皮細(xì)胞的穩(wěn)定性和功能。CDH5在生物學(xué)上的意義主要體現(xiàn)在其對(duì)血管內(nèi)皮細(xì)胞生物學(xué)的調(diào)控作用。它參與了多種生理過(guò)程，包括血管新生、血管穩(wěn)定和炎癥反應(yīng)。在腫瘤發(fā)生發(fā)展過(guò)程中，CDH5的表達(dá)水平和功能異常與腫瘤血管生成、腫瘤細(xì)胞的侵襲和轉(zhuǎn)移密切相關(guān)。此外，CDH5還參與了內(nèi)皮細(xì)胞的屏障功能和細(xì)胞信號(hào)傳導(dǎo)，影響細(xì)胞增殖、遷移和分化。因此，CDH5是血管相關(guān)疾病研究和治療中的一個(gè)重要靶點(diǎn)，例如在抗血管生成治療和腫瘤治療中具有潛在的應(yīng)用價(jià)值。
熱銷(xiāo)產(chǎn)品
CDH5 Antibody (CSB-PA07519A0Rb)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Mouse lung tissue, Mouse kidney tissue
All lanes: CDH5 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 88, 75 kDa
Observed band size: 88 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA07519A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Mouse Cadherin-5(CDH5) ELISA kit (CSB-EL005054MO)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL005054MO
規(guī)格：96T/48T
靈敏度：0.058 ng/mL
檢測(cè)范圍：0.235 ng/mL-15 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CDH5 Antibodies
CDH5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA868788 | Phospho-CDH5 (Tyr731) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA006270 | CDH5 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA006366 | Phospho-CDH5 (Y731) Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA006367 | CDH5 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA947781 | CDH5 Antibody | Human | ELISA,IHC |
| CSB-PA102499 | CDH5 Antibody | Human | ELISA,IHC |
| CSB-PA440133 | CDH5 Antibody | Human | ELISA,IHC |
| CSB-PA07519A0Rb | CDH5 Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA07519C0Rb | CDH5 Antibody, FITC conjugated | Human | |
| CSB-PA07519D0Rb | CDH5 Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA249655 | CDH5 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-MA554141 | CDH5 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
CDH5 Proteins
CDH5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP005054HU1 CSB-EP005054HU1 CSB-BP005054HU1 CSB-EP005054HU1-B |
Recombinant Human Cadherin-5 (CDH5), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF005054HU | Recombinant Human Cadherin-5 (CDH5) | in vitro E.coli expression system |
| CSB-MP005054HU1 | Recombinant Human Cadherin-5 (CDH5), Partial | Mammalian cell |
CDH5 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP005054MO1 CSB-EP005054MO1 CSB-BP005054MO1 CSB-MP005054MO1 CSB-EP005054MO1-B |
Recombinant Mouse Cadherin-5 (Cdh5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005054MO | Recombinant Mouse Cadherin-5 (Cdh5) | in vitro E.coli expression system |
CDH5 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP005054PI1 CSB-EP005054PI1 CSB-BP005054PI1 CSB-MP005054PI1 CSB-EP005054PI1-B |
Recombinant Pig Cadherin-5 (CDH5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005054PI | Recombinant Pig Cadherin-5 (CDH5) | in vitro E.coli expression system |
CDH5 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP764929BO CSB-EP764929BO CSB-BP764929BO CSB-MP764929BO CSB-EP764929BO-B |
Recombinant Bovine Cadherin-5 (CDH5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDH5 ELISA Kit
CDH5 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E09372h | Human Vascular Endothelial-Cadherin,VE-cad ELISA Kit | serum, plasma, tissue homogenates | 0.98 ng/mL |
CDH5 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL005054MO | Mouse Cadherin-5(CDH5) ELISA kit | serum, plasma, tissue homogenates | 0.058 ng/mL |
