CDH3
CDH3，即鈣黏蛋白3（Cadherin-3）又稱P-鈣黏蛋白，是鈣黏蛋白家族的重要成員，通過(guò)鈣離子依賴的細(xì)胞黏附機(jī)制參與組織形態(tài)發(fā)生和上皮屏障形成。該蛋白在胚胎發(fā)育期廣泛分布于胎盤、皮膚等組織，成年后主要表達(dá)于乳腺、前列腺等腺體基底細(xì)胞層。P-鈣黏蛋白通過(guò)與β-catenin等胞內(nèi)蛋白結(jié)合，調(diào)控Wnt信號(hào)通路活性，影響細(xì)胞極性和遷移能力。臨床上，CDH3異常表達(dá)與侵襲性乳腺癌（尤其是三陰性亞型）、胃癌轉(zhuǎn)移密切相關(guān)，其過(guò)表達(dá)可能通過(guò)破壞細(xì)胞間連接促進(jìn)腫瘤擴(kuò)散。在皮膚病領(lǐng)域，CDH3基因突變已被證實(shí)是先天性厚甲癥4B型的致病原因。目前針對(duì)P-鈣黏蛋白的藥物研發(fā)尚處早期階段，部分研究團(tuán)隊(duì)正在探索單克隆抗體和CAR-T細(xì)胞療法在乳腺癌治療中的應(yīng)用潛力。
熱銷產(chǎn)品
CDH3 Antibody (CSB-PA10715A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry analysis of human melanoma using CSB-PA10715A0Rb at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA10715A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CDH3 Antibodies
CDH3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005052GA01HU | CDH3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA10715A0Rb | CDH3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006358 | CDH3 Antibody | Human | WB, IHC, ELISA |
| CSB-PA037292 | CDH3 Antibody | Human | ELISA,WB |
| CSB-PA196946 | CDH3 Antibody | Human,Mouse | ELISA,WB,IHC |
CDH3 Proteins
CDH3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP005052HU1 CSB-EP005052HU1 CSB-BP005052HU1 CSB-MP005052HU1 CSB-EP005052HU1-B |
Recombinant Human Cadherin-3 (CDH3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005052HU | Recombinant Human Cadherin-3 (CDH3) | in vitro E.coli expression system |
CDH3 ELISA Kit
CDH3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08955h | Human Placenta Cadherin,P-cad ELISA Kit | Request Information |
