CD79A
CD79A，即B細(xì)胞抗原受體復(fù)合體α鏈，別名MB-1、IGA、Ig-alpha、IGAB、CD79amolecule。它是一種47kDa的膜糖蛋白，與CD79B結(jié)合形成異二聚體B細(xì)胞受體(BCR)，這種受體負(fù)責(zé)B細(xì)胞信號(hào)傳導(dǎo)，導(dǎo)致激活、凋亡或過敏。CD79A的作用機(jī)制主要是與CD79B共同參與B細(xì)胞受體的信號(hào)轉(zhuǎn)導(dǎo)。當(dāng)抗原與BCR結(jié)合后，CD79A/CD79B異二聚體能夠傳遞激活信號(hào)，引發(fā)B細(xì)胞的增殖、分化和抗體產(chǎn)生。CD79A的細(xì)胞質(zhì)區(qū)含有免疫受體酪氨酸激活基序(ITAM)，是信號(hào)轉(zhuǎn)導(dǎo)的關(guān)鍵結(jié)構(gòu)。CD79A對(duì)B細(xì)胞功能的重要調(diào)控作用，參與B細(xì)胞的抗原識(shí)別、激活、增殖和分化等過程。CD79A的表達(dá)還與某些B細(xì)胞腫瘤的發(fā)生發(fā)展相關(guān)，如B細(xì)胞急性淋巴細(xì)胞性白血病(B-ALL)等。CD79A是B細(xì)胞生物學(xué)研究和B細(xì)胞相關(guān)疾病治療的重要靶點(diǎn)。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD79A at 2 μg/ml can bind Anti-CD79A recombinant antibody(CSB-RA004957MA1HU). The EC50 is 1.521-1.700 ng/mL.
CD79A Recombinant Monoclonal Antibody (CSB-RA004957MA1HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of Human CD79A with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A(CSB-MP004957HU1) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 1.521-1.700 ng/mL.
The Binding Activity of Human CD79A&CD79B with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A&CD79B(CSB-MP5861HU) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 8.012-9.339 ng/mL.
The purity of CD79A was greater than 95% as determined by SEC-HPLC
The Binding Activity of Human CD79A with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A(CSB-MP004957HU1p6) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 14.44-16.80 ng/mL.
Untransfected HEK-293T cells (green line) and transfected Human CD79A&CD79B HEK-293T stable cells (red line) were stained with anti-CD79A antibody(CSB-RA004957MA1HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
Untransfected HEK-293T cells (green line) and transfected Human CD79A HEK-293T pool cells (red line) were stained with anti-CD79A antibody(CSB-RA004957MA1HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
CD79A Antibodies
CD79A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA165334 | CD79A Antibody | Human | ELISA,WB |
| CSB-PA080055 | CD79A Antibody | Human | WB, ELISA |
| CSB-PA080056 | CD79A Antibody | Human,Mouse | WB, ELISA |
| CSB-PA780889 | CD79A Antibody | Human,Mouse | ELISA,WB |
| CSB-PA183306 | CD79A Antibody | Human,Mouse | ELISA,WB |
| CSB-PA004957LA01HU | CD79A Antibody | Human | ELISA, IHC, IF |
| CSB-PA004957LB01HU | CD79A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004957LC01HU | CD79A Antibody, FITC conjugated | Human | |
| CSB-MA961575 | CD79A Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA004957MA1HU | CD79A Recombinant Monoclonal Antibody | Human | ELISA, FC |
CD79A Proteins
CD79A Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004957DO1 CSB-EP004957DO1 CSB-BP004957DO1 CSB-MP004957DO1 CSB-EP004957DO1-B |
Recombinant Dog B-cell antigen receptor complex-associated protein alpha chain (CD79A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004957DO | Recombinant Dog B-cell antigen receptor complex-associated protein alpha chain (CD79A) | in vitro E.coli expression system |
CD79A Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004957MO1 CSB-EP004957MO1 CSB-BP004957MO1 CSB-MP004957MO1 CSB-EP004957MO1-B |
Recombinant Mouse B-cell antigen receptor complex-associated protein alpha chain (Cd79a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004957MO | Recombinant Mouse B-cell antigen receptor complex-associated protein alpha chain (Cd79a) | in vitro E.coli expression system |
CD79A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004957HU1 CSB-EP004957HU1 CSB-BP004957HU1 CSB-EP004957HU1-B |
Recombinant Human B-cell antigen receptor complex-associated protein alpha chain (CD79A), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF004957HU | Recombinant Human B-cell antigen receptor complex-associated protein alpha chain (CD79A) | in vitro E.coli expression system |
| CSB-MP004957HU1 | Recombinant Human B-cell antigen receptor complex-associated protein alpha chain (CD79A）, partial (Active) | Mammalian cell |
| CSB-MP004957HU1p6 | Recombinant Human B-cell antigen receptor complex-associated protein alpha chain (CD79A), partial (Active) | Mammalian cell |
CD79A Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004957BO1 CSB-EP004957BO1 CSB-BP004957BO1 CSB-MP004957BO1 CSB-EP004957BO1-B |
Recombinant Bovine B-cell antigen receptor complex-associated protein alpha chain (CD79A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004957BO | Recombinant Bovine B-cell antigen receptor complex-associated protein alpha chain (CD79A) | in vitro E.coli expression system |
