CCL5
CCL5全稱為C-C基序趨化因子配體5，又稱RANTES（調(diào)節(jié)激活正常T細(xì)胞表達(dá)和分泌因子），是免疫系統(tǒng)重要的信號(hào)分子。CCL5主要由T淋巴細(xì)胞、血小板和某些上皮細(xì)胞分泌，能夠招募單核細(xì)胞、嗜酸性粒細(xì)胞等免疫細(xì)胞向炎癥部位聚集。通過與細(xì)胞表面CCR1、CCR3和CCR5等受體結(jié)合，不僅參與抗病毒免疫反應(yīng)，還與HIV病毒利用CCR5共受體入侵細(xì)胞的過程密切相關(guān)。在病理狀態(tài)下，CCL5過度表達(dá)與類風(fēng)濕性關(guān)節(jié)炎、動(dòng)脈粥樣硬化等慢性炎癥疾病相關(guān)，同時(shí)被發(fā)現(xiàn)能通過調(diào)控腫瘤微環(huán)境促進(jìn)乳腺癌、肺癌等惡性腫瘤的轉(zhuǎn)移。
近年針對(duì)CCL5及其受體的藥物開發(fā)取得進(jìn)展，抗HIV藥物馬拉維諾正是通過阻斷CCR5受體發(fā)揮作用。在癌癥治療領(lǐng)域，多個(gè)臨床前研究證實(shí)抑制CCL5可降低腫瘤侵襲性，相關(guān)單克隆抗體藥物已進(jìn)入Ⅰ期臨床試驗(yàn)。由于CCL5在抗感染與促腫瘤中存在雙重作用，其靶向治療需精準(zhǔn)調(diào)控表達(dá)水平，目前科研團(tuán)隊(duì)正探索基于納米載體的局部遞送系統(tǒng)以平衡療效與安全性。
熱銷產(chǎn)品
Recombinant Human C-C motif chemokine 5 (CCL5) (CSB-EP004800HUc7)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCL5 Antibody (CSB-PA05955A0Rb)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: CCL5 antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 10 kDa
Observed band size: 70 kDa
CCL5 Antibodies
CCL5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA05955A0Rb | CCL5 Antibody | Human | ELISA, WB |
| CSB-PA05955B0Rb | CCL5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA05959A0Rb | CCL5 Antibody | Human | ELISA, WB |
| CSB-PA040300 | CCL5 Antibody | Human,Mouse,Rat | IHC, ELISA |
CCL5 Proteins
CCL5 Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004800GU CSB-EP004800GU CSB-BP004800GU CSB-MP004800GU CSB-EP004800GU-B |
Recombinant Guinea pig C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004800HU CSB-BP004800HU CSB-MP004800HU CSB-EP004800HU-B |
Recombinant Human C-C motif chemokine 5 (CCL5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004800HUe0 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-EP004800HU | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-AP000871HU | Recombinant Human C-C motif chemokine 5 protein (CCL5) | E.Coli |
| CSB-EP004800HUc7 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-EP004800HUg5 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-EP004800HUd7 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
CCL5 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004800MO CSB-EP004800MO CSB-BP004800MO CSB-MP004800MO CSB-EP004800MO-B |
Recombinant Mouse C-C motif chemokine 5 (Ccl5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001241MO | Recombinant Mouse C-C motif chemokine 5 protein (Ccl5) | E.Coli |
CCL5 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004800RA CSB-EP004800RA CSB-BP004800RA CSB-MP004800RA CSB-EP004800RA-B |
Recombinant Rat C-C motif chemokine 5 (Ccl5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004800BO CSB-EP004800BO CSB-BP004800BO CSB-MP004800BO CSB-EP004800BO-B |
Recombinant Bovine C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP643672PI CSB-EP643672PI CSB-BP643672PI CSB-MP643672PI CSB-EP643672PI-B |
Recombinant Pig C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP808495DO CSB-EP808495DO CSB-BP808495DO CSB-MP808495DO CSB-EP808495DO-B |
Recombinant Dog C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP814163MOW CSB-EP814163MOW CSB-BP814163MOW CSB-MP814163MOW CSB-EP814163MOW-B |
Recombinant Macaca mulatta C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Sigmodon hispidus (Hispid cotton rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP842062SZK CSB-EP842062SZK CSB-BP842062SZK CSB-MP842062SZK CSB-EP842062SZK-B |
Recombinant Sigmodon hispidus C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP844627CA CSB-EP844627CA CSB-BP844627CA CSB-MP844627CA CSB-EP844627CA-B |
Recombinant Cat C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP847581HO CSB-EP847581HO CSB-BP847581HO CSB-MP847581HO CSB-EP847581HO-B |
Recombinant Horse C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 ELISA Kit
CCL5 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL004800DO | Dog C-C motif chemokine 5(CCL5) ELISA kit | serum, plasma, tissue homogenates | 0.081 ng/mL |
CCL5 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17375h | Human C-C motif chemokine 5 (CCL5/D17S136E/SCYA5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 2.307 pg/mL |
CCL5 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09256m | Mouse regulated on activation in normal T-cell expressed and secreted,RANTES ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
CCL5 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07398r | Rat regulated on activation in normal T-cell expressed and secreted/C-C motif chemokine 5 (RANTES/CCL5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 ng/mL |
