BCAT2
支鏈氨基酸轉(zhuǎn)氨酶2（BCAT2）是一種線粒體酶，主要負責亮氨酸、異亮氨酸和纈氨酸三種支鏈氨基酸的代謝，通過催化其轉(zhuǎn)氨基反應生成相應的支鏈α-酮酸。該酶在肝臟、骨骼肌等能量代謝活躍的組織中高表達，因其線粒體定位特征，也被稱為BCATm。研究發(fā)現(xiàn)，BCAT2通過調(diào)控支鏈氨基酸分解代謝，影響細胞能量供應和蛋白質(zhì)合成，其異常表達與代謝綜合征、糖尿病等疾病密切相關(guān)。近年來在腫瘤領(lǐng)域，BCAT2被發(fā)現(xiàn)可通過維持白血病干細胞內(nèi)支鏈氨基酸水平，促進急性髓系白血病進展，成為潛在治療靶點。目前針對BCAT2的藥物開發(fā)尚處于早期階段，有研究嘗試通過小分子抑制劑阻斷其酶活性，但尚無進入臨床試驗的候選藥物。值得注意的是，由于支鏈氨基酸代謝與mTOR信號通路的交互作用，針對該酶的調(diào)控可能為代謝性疾病和癌癥治療提供新思路。
熱銷產(chǎn)品
Recombinant Human Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) (CSB-EP002601HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BCAT2 Antibody (CSB-PA002601LA01HU)
驗證數(shù)據(jù)
Western blot
All lanes: BCAT2 antibody at 2µg/ml
Lane 1: NIH/3T3 whole cell lysate
Lane 2: Mouse kidney tissue
Lane 3: Mouse spleen tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 45, 34 kDa
Observed band size: 45 kDa
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA002601LA01HU at dilution of 1:100
BCAT2 Antibodies
BCAT2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA002601GA01HU | BCAT2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA002601LA01HU | BCAT2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA002601ESR1HU | BCAT2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA842510 | BCAT2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA129399 | BCAT2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
BCAT2 Proteins
BCAT2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002601HU CSB-BP002601HU CSB-MP002601HU CSB-EP002601HU-B |
Recombinant Human Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002601HU | Recombinant Human Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) | E.coli |
