BARD1
BARD1,即BRCA1相關RING域蛋白1,別名BRCC3、BARD-1、BRCC45、BRCC等。BARD1是一種E3泛素連接酶,與BRCA1蛋白形成復合物,參與DNA雙鏈斷裂的修復過程。BARD1的作用機制包括促進DNA末端切除和保護DNA復制叉免受非計劃性降解。BARD1-BRCA1復合物直接促進由EXO1或DNA2核酸酶催化的長距離DNA末端切除途徑,并在DNA2依賴途徑中刺激Werner或Bloom解旋酶的DNA解旋活動。BARD1-BRCA1復合物還與MRE11-RAD50-NBS1和磷酸化CtIP形成BRCA1-C復合物,協同刺激切除作用。BARD1對于維持基因組穩定性和防止癌癥發生至關重要,其功能異常與多種癌癥的發生發展相關。
熱銷產品
BARD1 Antibody (CSB-PA860351LA01HU)
驗證數據

Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, 293 whole cell lysate, U87 whole cell lysate, SH-SY5Y whole cell lysate
All lanes: BARD1 antibody at 3.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 87, 85, 76, 15 kDa
Observed band size: 87 kDa
BARD1 Antibodies
BARD1 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA138883 | BARD1 Antibody | Human | ELISA,WB |
CSB-PA000974 | BARD1 Antibody | Human | WB, IHC, ELISA |
CSB-PA860351LA01HU | BARD1 Antibody | Human | ELISA, WB |
CSB-PA860351LB01HU | BARD1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA860351LC01HU | BARD1 Antibody, FITC conjugated | Human | |
CSB-PA860351LD01HU | BARD1 Antibody, Biotin conjugated | Human | ELISA |
BARD1 Proteins
BARD1 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP860351HU1 CSB-EP860351HU1 CSB-BP860351HU1 CSB-MP860351HU1 CSB-EP860351HU1-B |
Recombinant Human BRCA1-associated RING domain protein 1 (BARD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |