ARHGEF4
Rho guanine nucleotide exchange factor 4 is a protein in humans that is encoded by ARHGEF4 gene. Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
ARHGEF4 Proteins
ARHGEF4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP766503MO CSB-EP766503MO CSB-BP766503MO CSB-MP766503MO CSB-EP766503MO-B |
Recombinant Mouse Rho guanine nucleotide exchange factor 4 (Arhgef4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ARHGEF4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP882083HU CSB-EP882083HU CSB-BP882083HU CSB-MP882083HU CSB-EP882083HU-B |
Recombinant Human Rho guanine nucleotide exchange factor 4 (ARHGEF4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
