AKAP8
AKAP8 is a protein in humans that is encoded by AKAP8 gene. Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation.
AKAP8 Antibodies
AKAP8 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA091575 | AKAP8 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000845 | AKAP8 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA943275 | AKAP8 Antibody | Human | ELISA,WB,IHC |
| CSB-PA145524 | AKAP8 Antibody | Human | ELISA,WB,IHC |
AKAP8 Proteins
AKAP8 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP001530HU CSB-BP001530HU CSB-MP001530HU CSB-EP001530HU-B |
Recombinant Human A-kinase anchor protein 8 (AKAP8) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001530HU | Recombinant Human A-kinase anchor protein 8 (AKAP8), partial | E.coli |
AKAP8 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP713339DO CSB-EP713339DO CSB-BP713339DO CSB-MP713339DO CSB-EP713339DO-B |
Recombinant Dog A-kinase anchor protein 8 (AKAP8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AKAP8 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP730871RA CSB-EP730871RA CSB-BP730871RA CSB-MP730871RA CSB-EP730871RA-B |
Recombinant Rat A-kinase anchor protein 8 (Akap8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AKAP8 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP866745MO CSB-EP866745MO CSB-BP866745MO CSB-MP866745MO CSB-EP866745MO-B |
Recombinant Mouse A-kinase anchor protein 8 (Akap8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
