ACVR2A

ACVR2A，即激活素A型II型受體A，別名ACVR2、ACTRII。它是由ACVR2A基因編碼的跨膜絲氨酸/蘇氨酸激酶受體，屬于轉化生長因子-β(TGF-β)超家族。ACVR2A主要在多種組織中表達，如皮膚和膽囊。其作用機制涉及與激活素A結合后，招募并磷酸化I型激活素受體，通過SMAD2/3蛋白發出信號，進而影響細胞命運。ACVR2A對組織再生、細胞分化和腫瘤發展等過程具有重要影響。ACVR2A在某些類型的癌癥中表達下調，可能與腫瘤的轉移潛能和患者的預后相關。

熱銷產品

Recombinant Human/Cynomolgus Activin receptor type-2A (ACVR2A), partial (Active) (CSB-MP001260HU1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2A at 2 μg/ml can bind Anti-ACVR2A&ACVR2B recombinant antibody (CSB-RA623829MA1HU). The EC₅₀ is 3.848-4.375 ng/mL.

Recombinant Mouse Activin receptor type-2A (Acvr2a), partial (Active) (CSB-MP001260MO1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Acvr2a at 2 μg/ml can bind Anti-ACVR2A&ACVR2B recombinant antibody (CSB-RA623829MA1HU). The EC₅₀ is 1.562-1.966 ng/mL.

The purity of ACVR2A was greater than 95% as determined by SEC-HPLC

ACVR2A&ACVR2B Recombinant Monoclonal Antibody (CSB-RA623829MA1HU)

驗證數據

The Binding Activity of Human ACVR2A with Anti-ACVR2A&ACVR2B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2A（CSB-MP001260HU1）at 2 μg/mL can bind Anti-ACVR2A&ACVR2B recombinant antibody . The EC₅₀ is 3.848-4.375 ng/mL.

The Binding Activity of Mouse ACVR2A with Anti-ACVR2A&ACVR2B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse ACVR2A（CSB-MP001260MO1） at 2 μg/mL can bind Anti-ACVR2A&ACVR2B recombinant antibody. The EC₅₀ is 1.562-1.966 ng/mL.

The Binding Activity of Mouse Acvr2b with Anti-ACVR2A&ACVR2B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Acvr2b（CSB-MP001261MO1） at 2 μg/mL can bind Anti-ACVR2A&ACVR2B recombinant antibody. The EC₅₀ is 3.560-4.235 ng/mL.

The Binding Activity of Human ACVR2B with Anti-ACVR2A&ACVR2B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2B（CSB-MP623829HU） at 2 μg/mL can bind Anti-ACVR2A&ACVR2B recombinant antibody. The EC₅₀ is 2.983-3.438 ng/mL.

IHC image of CSB-RA623829MA1HU diluted at 1:200 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA623829MA1HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of SH-SY5Y cell with CSB-RA623829MA1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).

The purity of ACVR2A&ACVR2B was greater than 95% as determined by SEC-HPLC

ACVR2A Antibody

ACVR2A Protein

ACVR2A Antibodies

ACVR2A for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA001260ESR1HU	ACVR2A Antibody	Human	ELISA, IHC
CSB-PA001260ESR2HU	ACVR2A Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA070256	ACVR2A Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA110386	ACVR2A Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA104519	ACVR2A Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA055681	ACVR2A Antibody	Human,Mouse,Rat	ELISA,WB,IHC

ACVR2A Proteins

ACVR2A Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP001260MO1 CSB-EP001260MO1 CSB-BP001260MO1 CSB-EP001260MO1-B	Recombinant Mouse Activin receptor type-2A (Acvr2a), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-CF001260MO	Recombinant Mouse Activin receptor type-2A (Acvr2a)	in vitro E.coli expression system

ACVR2A Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-EP001260HU1 CSB-BP001260HU1 CSB-EP001260HU1-B	Recombinant Human Activin receptor type-2A (ACVR2A), partial	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-CF001260HU	Recombinant Human Activin receptor type-2A (ACVR2A)	in vitro E.coli expression system
CSB-MP001260HU1	Recombinant Human/Cynomolgus Activin receptor type-2A (ACVR2A), partial (Active)	Mammalian cell
CSB-YP001260HU1	Recombinant Human/Cynomolgus Activin receptor type-2A (ACVR2A), partial (Active)	Yeast

ACVR2A Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP001260RA1 CSB-EP001260RA1 CSB-BP001260RA1 CSB-MP001260RA1 CSB-EP001260RA1-B	Recombinant Rat Activin receptor type-2A (Acvr2a), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF001260RA	Recombinant Rat Activin receptor type-2A (Acvr2a)	in vitro E.coli expression system

ACVR2A Proteins for Xenopus laevis (African clawed frog)

產品貨號	產品名稱	來源
CSB-YP001260XBE1 CSB-EP001260XBE1 CSB-BP001260XBE1 CSB-MP001260XBE1 CSB-EP001260XBE1-B	Recombinant Xenopus laevis Activin receptor type-2A (acvr2a), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF001260XBE	Recombinant Xenopus laevis Activin receptor type-2A (acvr2a)	in vitro E.coli expression system

ACVR2A Proteins for Ovis aries (Sheep)

產品貨號	產品名稱	來源
CSB-YP631719SH CSB-EP631719SH CSB-BP631719SH CSB-MP631719SH CSB-EP631719SH-B	Recombinant Sheep Activin receptor type-2A (ACVR2A), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACVR2A Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP635678BO CSB-EP635678BO CSB-BP635678BO CSB-MP635678BO CSB-EP635678BO-B	Recombinant Bovine Activin receptor type-2A (ACVR2A), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACVR2A Proteins for Gallus gallus (Chicken)

產品貨號	產品名稱	來源
CSB-YP845865CH CSB-EP845865CH CSB-BP845865CH CSB-MP845865CH CSB-EP845865CH-B	Recombinant Chicken Activin receptor type-2A (ACVR2A), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli