NTRK2
NTRK2全稱為神經(jīng)營養(yǎng)酪氨酸激酶受體2型（Neurotrophic Tyrosine Kinase Receptor Type 2），常簡稱為TrkB或GP145-TrkB。NTRK2是腦源性神經(jīng)營養(yǎng)因子（BDNF）的主要受體，通過與配體結(jié)合激活下游信號網(wǎng)絡(luò)，調(diào)控神經(jīng)元存活、突觸可塑性和神經(jīng)遞質(zhì)釋放，對學(xué)習(xí)記憶、情緒調(diào)節(jié)等腦功能至關(guān)重要。NTRK2信號異常與阿爾茨海默病、抑郁癥、癲癇等神經(jīng)系統(tǒng)疾病密切相關(guān)，其過度激活也可能導(dǎo)致神經(jīng)母細(xì)胞瘤、肺癌等實體瘤的發(fā)生。近年來針對NTRK基因家族融合突變的靶向治療取得突破，拉羅替尼（Larotrectinib）和恩曲替尼（Entrectinib）等泛TRK抑制劑已獲批用于NTRK融合陽性的實體瘤患者，但部分患者用藥后出現(xiàn)的激酶區(qū)耐藥突變?nèi)允桥R床挑戰(zhàn)。目前第二代TRK抑制劑如Selitrectinib正在研發(fā)中，旨在克服獲得性耐藥問題。
熱銷產(chǎn)品
NTRK2 Recombinant Monoclonal Antibody (CSB-RA619082MA1HU)
驗證數(shù)據(jù)
Immunofluorescence staining of SH-SY5Y cell with CSB-RA619082MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
NTRK2 Antibodies
NTRK2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA016134GA01HU | NTRK2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA619082ESR1HU | NTRK2 Antibody | Human | ELISA, IHC |
| CSB-PA197704 | Phospho-NTRK2 (Tyr515) Antibody | Human,Mouse,Rat | ELISA,IF |
| CSB-PA108948 | Phospho-NTRK2 (Tyr705) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA292268 | NTRK2 (Ab-705) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA789970 | Phospho-NTRK2 (Tyr706/Tyr707) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA936032 | NTRK2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA004332 | NTRK2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020171 | Phospho-NTRK2 (Y516) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020172 | Phospho-NTRK2 (Y706) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA020173 | Phospho-NTRK2 (Y706/Y707) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA020174 | NTRK2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-RA619082MA1HU | NTRK2 Recombinant Monoclonal Antibody | Human | ELISA, IF |
NTRK2 Proteins
NTRK2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016134MO1 CSB-EP016134MO1 CSB-BP016134MO1 CSB-MP016134MO1 CSB-EP016134MO1-B |
Recombinant Mouse BDNF/NT-3 growth factors receptor (Ntrk2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016134MO | Recombinant Mouse BDNF/NT-3 growth factors receptor (Ntrk2) | in vitro E.coli expression system |
NTRK2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP619082HU CSB-EP619082HU CSB-BP619082HU CSB-MP619082HU CSB-EP619082HU-B |
Recombinant Human BDNF/NT-3 growth factors receptor (NTRK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTRK2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP720531RA CSB-EP720531RA CSB-BP720531RA CSB-MP720531RA CSB-EP720531RA-B |
Recombinant Rat BDNF/NT-3 growth factors receptor (Ntrk2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTRK2 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP845939CH CSB-EP845939CH CSB-BP845939CH CSB-MP845939CH CSB-EP845939CH-B |
Recombinant Chicken BDNF/NT-3 growth factors receptor (NTRK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
