IL6R
IL6R，即白介素6受體，別名Interleukin-6 receptor subunit alpha、Membrane glycoprotein 80、MGC30256。它是一種由IL6R基因編碼的蛋白質(zhì)，屬于免疫球蛋白超家族成員，主要在肝臟、巨噬細(xì)胞、T細(xì)胞等細(xì)胞表面表達(dá)。IL6R的作用機(jī)制主要是通過(guò)與IL-6結(jié)合，形成IL-6/IL-6R復(fù)合物，進(jìn)而與信號(hào)轉(zhuǎn)導(dǎo)蛋白gp130結(jié)合，激活JAK/STAT、MAPK、PI3K等下游信號(hào)通路，參與調(diào)節(jié)細(xì)胞增殖、分化、免疫應(yīng)答等多種生物學(xué)過(guò)程。IL6R參與了機(jī)體的免疫反應(yīng)、炎癥反應(yīng)、造血、代謝等多種生理過(guò)程。IL6R的表達(dá)水平在多種疾病中發(fā)生變化，如類風(fēng)濕性關(guān)節(jié)炎、系統(tǒng)性紅斑狼瘡、多發(fā)性骨髓瘤等，因此，IL6R是自身免疫性疾病和炎癥性疾病治療的重要靶點(diǎn)。IL-6與其受體結(jié)合后，可以調(diào)節(jié)B細(xì)胞和T細(xì)胞的分化、促進(jìn)肝細(xì)胞產(chǎn)生急性期蛋白、影響神經(jīng)細(xì)胞分化等，對(duì)于維持機(jī)體穩(wěn)態(tài)和防御功能具有重要作用。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
Western Blot analysis of AD293, 4T1 cells using IL-6Rα Polyclonal Antibody.
IL6R Antibodies
IL6R for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006108 | IL6R Antibody | Human | WB, ELISA |
IL6R Proteins
IL6R Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011665RA1 CSB-EP011665RA1 CSB-BP011665RA1 CSB-MP011665RA1 CSB-EP011665RA1-B |
Recombinant Rat Interleukin-6 receptor subunit alpha (Il6r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011665RA | Recombinant Rat Interleukin-6 receptor subunit alpha (Il6r) | in vitro E.coli expression system |
IL6R Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011665HU | Recombinant Human Interleukin-6 receptor subunit alpha (IL6R), partial | Yeast |
| CSB-EP011665HU CSB-BP011665HU CSB-MP011665HU CSB-EP011665HU-B |
Recombinant Human Interleukin-6 receptor subunit alpha (IL6R), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6R Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011665PI1 CSB-BP011665PI1 CSB-MP011665PI1 CSB-EP011665PI1-B |
Recombinant Pig Interleukin-6 receptor subunit alpha (IL6R), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011665PI | Recombinant Pig Interleukin-6 receptor subunit alpha (IL6R) | in vitro E.coli expression system |
IL6R ELISA Kit
IL6R ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E16524h | Human Interleukin 6 receptor(IL-6R)ELISA Kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
IL6R ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11876r | Rat Interleukin 6 receptor,IL-6R ELISA Kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
