據估計，慢性腎臟?。–KD）影響著全球8.5億多人，2019年導致310多萬人死亡 [1]。目前，腎臟病是導致死亡的第8大原因 [2]，如果不加以解決，預計到2040年，它將成為導致壽命損失的第5大原因 [3]。
鑒于當前全球慢性腎臟病發病率不斷上升，而公眾對該病的防治知識還有待提高，經國際腎臟病學會與國際腎臟基金聯盟聯合提議，決定從2006年起將每年3月份的第二個星期四確定為世界腎臟日，目的在于提高人們對慢性腎臟病以及相關的心血管疾病和死亡率的認識，并重視在慢性腎臟病的早期的檢測和預防方面全球的迫切需求。
2024年3月14日，是第17個世界腎臟日，主題為“關注腎臟護理中的差距：將我們的知識轉化為我們的行動”[4]。從歷史上看，新療法從臨床證據轉化為日常實踐平均需要17年時間。鑒于目前已有的預防或延緩腎病發病和進展的高效治療方法，這個時間太長了。對于預防和管理腎臟疾病的常見風險因素，如高血壓和糖尿病，已有明確的指導原則。對于高血壓和糖尿病等腎臟疾病常見風險因素的預防和管理，已經有了明確的指導方針，但全世界只有一小部分患有這些疾病的人得到了治療和診斷，而絕大多數腎病患者都不知道自己的病情，因為腎病在早期往往是無聲無息的。因此，腎病的早期檢測和防治至關重要，而對于其致病機制的研究，相關信號通路研究、標志物的開發，也是科學家們一直在研究和探索的方向。
華美生物自成立至今，已有17年，長期致力于為科研工作者提供高質量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產品。特篩選了針對腎臟病研究熱度最高的25個靶點，并整理了相關的試劑產品列舉如下，供您選擇：
華美生物蛋白產品：
| 產品名稱 | 貨號 | 靶點 | 來源 | 蛋白標簽 |
|---|---|---|---|---|
| Recombinant Enterobacteria phage T4 DNA alpha-glucosyltransferase (agt) | CSB-EP356278EDZ | agt | E.coli | N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged |
| Recombinant Human RAC-alpha serine/threonine-protein kinase (AKT1) | CSB-EP001553HU | AKT1 | E.coli | N-terminal GST-tagged |
| Recombinant Rat RAC-alpha serine/threonine-protein kinase (Akt1) | CSB-EP001553RA | Akt1 | E.coli | N-terminal 10xHis-tagged |
| Recombinant Mouse Serum albumin (Alb) | CSB-BP001561MO | Alb | Baculovirus | C-terminal 9xHis-tagged |
| Recombinant Macaca fascicularis albumin (ALB) | CSB-MP001561MOV | ALB | Mammalian cell | N-terminal 6xHis-Myc-tagged |
| Recombinant Dog Serum albumin (ALB) | CSB-YP001561DO | ALB | Yeast | N-terminal 6xHis-tagged |
| Recombinant Mouse Albumin (Alb) | CSB-YP001561MO | Alb | Yeast | N-terminal 6xHis-tagged |
| Recombinant Macaca fascicularis albumin (ALB) | CSB-YP001561MOV | ALB | Yeast | N-terminal 6xHis-tagged |
| Recombinant Bovine Serum albumin (ALB) | CSB-YP001561BO | ALB | Yeast | C-terminal 6xHis-Myc-tagged |
| Recombinant Chicken Serum albumin (ALB), partial | CSB-YP001561CH | ALB | Yeast | C-terminal 6xHis-tagged |
| Recombinant Chicken Albumin (ALB), partial | CSB-EP001561CH | ALB | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Rat Serum albumin (Alb) | CSB-EP001561RA | Alb | E.coli | N-terminal 6xHis-tagged and C-terminal Avi-tagged |
| Recombinant Human C-C motif chemokine 2 (CCL2) | CSB-EP004783HUb1 | CCL2 | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Mouse C-C motif chemokine 2 (Ccl2), partial | CSB-EP004783MO | CCL2 | E.coli | N-terminal 6xHis-tagged |
| Recombinant Human CD59 glycoprotein (CD59) | CSB-EP004947HU | CD59 | E.coli | N-terminal GST-tagged |
| Recombinant Human CD59 glycoprotein (CD59) | CSB-YP004947HU | CD59 | Yeast | N-terminal 6xHis-tagged |
| Recombinant Mouse Cystatin-C (Cst3) | CSB-EP006091MO | Cst3 | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Human Epidermal growth factor receptor (EGFR), partial | CSB-EP007479HU3 | EGFR | E.coli | N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged |
| Recombinant Human Epidermal growth factor receptor (EGFR), partial | CSB-EP007479HU | EGFR | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) | CSB-MP007479HU | EGFR | Mammalian cell | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
華美生物抗體產品：
● 重組抗體：
| 產品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
|---|---|---|---|---|
| ACE Recombinant Monoclonal Antibody | CSB-RA268157A0HU | ACE | Human | ELISA, IHC |
| AGT Recombinant Monoclonal Antibody | CSB-RA263831A0HU | AGT | Human | ELISA, IHC |
| Phospho-AKT1 (T450) Recombinant Monoclonal Antibody | CSB-RA001553A450phHU | AKT1 | Human | ELISA, WB |
| Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody | CSB-RA001553A473phHU | AKT1 | Human | ELISA, WB, IHC, IF, IP |
| AKT1 Recombinant Monoclonal Antibody | CSB-RA917625A0HU | AKT1 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
| CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
| CD59 Recombinant Monoclonal Antibody | CSB-RA046065A0HU | CD59 | Human | ELISA, FC |
| CRP Recombinant Monoclonal Antibody | CSB-RA988767A0HU | CRP | Human | ELISA, IHC |
| Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
| Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
| EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
| EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
| EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
| IL6 Recombinant Monoclonal Antibody | CSB-RA011664MA1HU | IL6 | Human | ELISA |
| INS Recombinant Monoclonal Antibody | CSB-RA584163A0HU | INS | Human | ELISA, IHC |
| Phospho-MTOR (S2481) Recombinant Monoclonal Antibody | CSB-RA008968A2481phHU | MTOR | Human | ELISA, WB, IF |
| Phospho-MTOR (S2448) Recombinant Monoclonal Antibody | CSB-RA008968A2448phHU | MTOR | Human | ELISA, WB, IHC, IF |
● 單克隆抗體：
| 產品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
|---|---|---|---|---|
| ACE Monoclonal Antibody | CSB-MA904961 | ACE | Human,Mouse,Rat | ELISA, WB |
| AKT1 Monoclonal Antibody | CSB-MA011037 | AKT1 | Human,Mouse,Pig,Rat | ELISA, WB |
| ALB Monoclonal Antibody | CSB-MA076752 | ALB | Human | ELISA, WB, IHC |
| CCL2 Monoclonal Antibody | CSB-MA058641A0m | CCL2 | Human | ELISA, IHC |
| CD4 Monoclonal Antibody | CSB-MA000228 | CD4 | Human,Mouse,Rat | ELISA, IHC |
| CD4 Monoclonal Antibody,APC Conjugated | CSB-MA043428 | CD4 | Human | ELISA, IF, FC |
| CD4 Monoclonal Antibody,Biotin Conjugated | CSB-MA981329 | CD4 | Human | ELISA, IF, FC |
| CD4 Monoclonal Antibody,FITC Conjugated | CSB-MA124048 | CD4 | Human | ELISA, IF, FC |
| CD4 Monoclonal Antibody,PE Conjugated | CSB-MA260243 | CD4 | Human | ELISA, IF, FC |
| CD4 Monoclonal Antibody,PE-Cy5 Conjugated | CSB-MA570802 | CD4 | Human | ELISA, IF, FC |
| CD4 Monoclonal Antibody,Purified | CSB-MA783233 | CD4 | Human | ELISA, FC |
| CD4 Monoclonal Antibody,PE Conjugated | CSB-MA084552 | CD4 | Mouse | ELISA, FC |
| CD59 Monoclonal Antibody | CSB-MA0049471A0m | CD59 | Human | ELISA, WB, IHC |
| CRP Monoclonal Antibody | CSB-MA027411E0m | CRP | Human | ELISA, IHC |
| CST3 Monoclonal Antibody | CSB-MA061901A0m | CST3 | Human | ELISA, IHC |
| EGFR Monoclonal Antibody | CSB-MA000199 | EGFR | Human | ELISA, WB, IHC, IF |
| EGFR Monoclonal Antibody | CSB-MA000293 | EGFR | Human | ELISA, WB |
| IL6 Monoclonal Antibody | CSB-MA067571A0m | IL6 | Human | ELISA, WB, IHC |
| LCN2 Monoclonal Antibody | CSB-MA068302A0m | LCN2 | Human,Mouse | ELISA, WB, IHC |
| LCN2 Monoclonal Antibody | CSB-MA068341A0m | LCN2 | Human,Mouse | ELISA, WB |
| PTH Monoclonal Antibody | CSB-MA0189871A0m | PTH | Human | ELISA |
| TNF Monoclonal Antibody | CSB-MA084771A0m | TNF | Bovine | ELISA |
| TNF Monoclonal Antibody | CSB-MA080271 | TNF | Human,Mouse,Rat | ELISA, WB, IHC |
| TNF Monoclonal Antibody | CSB-MA080272 | TNF | Human,Mouse,Rat | ELISA, WB, IHC |
● 多克隆抗體：
| 產品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
|---|---|---|---|---|
| Ace Antibody | CSB-PA001149LA01RA | Ace | Rat | ELISA, IHC |
| Ace Antibody, HRP conjugated | CSB-PA001149LB01RA | Ace | Rat | ELISA |
| Ace Antibody, FITC conjugated | CSB-PA001149LC01RA | Ace | Rat | |
| Ace Antibody, Biotin conjugated | CSB-PA001149LD01RA | Ace | Rat | ELISA |
| ACE Antibody | CSB-PA007661 | ACE | Human, Mouse, Rat | ELISA, WB, IHC |
| ACE Antibody | CSB-PA794185 | ACE | Human, Mouse | ELISA, IHC |
| ACE Antibody | CSB-PA152113 | ACE | Human, Mouse, Rat | ELISA, WB |
| ACE Antibody | CSB-PA172536 | ACE | Human, Mouse, Rat | ELISA, WB |
| ACE Antibody | CSB-PA271234 | ACE | Human, Mouse, Rat | ELISA, WB, IHC |
| ACE Antibody | CSB-PA575032 | ACE | Human, Mouse, Rat | ELISA, WB, IHC |
| AGT Antibody | CSB-PA10079A0Rb | AGT | Human | ELISA, WB, IHC, IF |
| AGT Antibody, HRP conjugated | CSB-PA10079B0Rb | AGT | Human | ELISA |
| AGT Antibody, FITC conjugated | CSB-PA10079C0Rb | AGT | Human | |
| AGT Antibody, Biotin conjugated | CSB-PA10079D0Rb | AGT | Human | ELISA |
| AGT Antibody | CSB-PA001463ESR1HU | AGT | Human | ELISA, IHC, IF |
| AGT Antibody | CSB-PA001463ESR2HU | AGT | Human, Mouse | ELISA, WB, IHC, IF |
| AGT Antibody | CSB-PA001463EA01HU | AGT | Human, Rat | ELISA, WB, IHC |
| AGT Antibody, HRP conjugated | CSB-PA001463EB01HU | AGT | Human | ELISA |
| AGT Antibody, FITC conjugated | CSB-PA001463EC01HU | AGT | Human | |
| AGT Antibody, Biotin conjugated | CSB-PA001463ED01HU | AGT | Human | ELISA |
華美生物ELISA試劑盒產品：
| 產品名稱 | 貨號 | 靶點 | 檢測范圍 | 靈敏度 |
|---|---|---|---|---|
| 大鼠血管緊張素轉化酶(ACE)酶聯免疫試劑盒 | CSB-E04490r | ACE | 31.25 ng/ml - 2000 ng/ml | 7.81 ng/ml |
| 小鼠血管緊張素轉化酶(ACE)酶聯免疫試劑盒 | CSB-E04492m | ACE | 1.56 ng/mL-100 ng/mL | 0.39 ng/mL |
| 人血管緊張素Ⅰ轉化酶(ACEⅠ)酶聯免疫試劑盒 | CSB-E11269h | ACE | 18.75 pg/mL-1200 pg/mL | 4.7 pg/mL |
| 人血管緊張素原(aGT)酶聯免疫試劑盒 | CSB-E08564h | AGT | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
| 大鼠血管緊張素原(aGT)酶聯免疫試劑盒 | CSB-E08565r | AGT | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
| 小鼠血管緊張素原(aGT)酶聯免疫試劑盒 | CSB-E08566m | AGT | 3.12 ng/mL-200 ng/mL | 0.78 ng/mL |
| 人RACα絲氨酸/蘇氨酸蛋白激酶(AKT1)酶聯免疫試劑盒 | CSB-EL001553HU | AKT1 | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |
| 牛白蛋白(ALB)酶聯免疫試劑盒 | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
| 小鼠白蛋白酶聯免疫試劑盒 | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
| 犬白蛋白(Alb)酶聯免疫試劑盒 | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
| 綿羊白蛋白酶聯免疫試劑盒 | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
| 馬白蛋白酶聯免疫試劑盒 | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
| 豬白蛋白酶聯免疫試劑盒 | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
| 山羊白蛋白(Alb)酶聯免疫試劑盒 | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
| 豚鼠白蛋白(ALB)酶聯免疫試劑盒 | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
| 兔白蛋白酶聯免疫試劑盒 | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
| 人單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E04655h | CCL2 | 6.25 pg/ml-400 pg/ml. | 1.56 pg/ml. |
| 小鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E07430m | CCL2 | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
| 犬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E15747c | CCL2 | 0.125 ng/mL-8 ng/mL | 0.147 ng/mL |
| 兔子單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E06921Rb | CCL2 | 23.5 pg/mL-1500 pg/mL | 5.87 pg/mL |
參考文獻：
[1] https://vizhub.healthdata.org/gbd-results/
[2] https://www.healthdata.org/news-events/newsroom/news-releases/lancet-latest-global-disease-estimates-reveal-perfect-storm
[3] https://www.thelancet.com/pdfs/journals/lancet/PlIS0140-6736(18)31694-5.pdf
[4] https://www.worldkidneyday.org/knowledge-bank-files/wkd-2024-scientific-editorial-mind-the-gap-in-kidney-care-translating-what-we-know-into-what-we-do/
