Recombinant Human Guanine nucleotide exchange factor VAV3 (VAV3), partial
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中文名稱：人VAV3重組蛋白
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貨號(hào)：CSB-EP892140HU-B
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說明書：
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規(guī)格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產(chǎn)品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：FLJ40431; Guanine nucleotide exchange factor VAV3; Protein vav 3; Protein vav3; RGD1565941; VAV 3; Vav 3 guanine nucleotide exchange factor; VAV 3 oncogene; VAV 3 protein; VAV-3; Vav3; VAV3 oncogene; VAV3 protein; VAV3_HUMAN
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種屬：Homo sapiens (Human)
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蛋白長(zhǎng)度：Partial
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蛋白標(biāo)簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復(fù)溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲(chǔ)存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項(xiàng)：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion.
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基因功能參考文獻(xiàn)：
- The N-terminal truncated Vav3.1 may be decisively involved in mechanisms causing genuine multi-drug resistance. PMID: 29194596
- VAV3 polymorphisms associate with cardiovascular risk factors and target organ damage. PMID: 28157227
- High VAV3 variant expression is associated with endometrial cancer. PMID: 30083818
- Results identified the diffuse B-cell lymphoma homology (DH) domain of Vav3 that interacts with the N-terminal region of AR-V7 (splice variants) and increases its expression in castration-resistant prostate cancer (CRPC). This interaction disrupted AR-V7 interaction with other AR coactivators like Src1 and Vav2. PMID: 28811363
- We then explore the consequences of phorbol ester binding to a modified Vav3 in which the C1 domain has been altered to allow phorbol ester binding. We find both disruption of the guanyl nucleotide exchange activity of the modified Vav 3 as well as a shift in localization to the membrane upon phorbol ester treatment. PMID: 28927664
- Overexpression of Vav3 is an independent risk factor for prognosis of gastric cancer, and can be used as a prognostic indicator. PMID: 28285969
- Vav3 is a novel TRAF6 interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex. PMID: 27507811
- this study shows that the anti-tumor effects of astragaloside IV are mediated by the downregulation of Vav3-mediated Rac1/MAPK activation PMID: 27930970
- Our results indicated that individuals carrying the VAV3 rs7528153 TT genotype were at a significantly increased risk of developing Paget's Disease of Bone PMID: 27172236
- Vav3 was accumulated in cell protrusions, contributed to the formation of membrane protrusions, and thereby increased the motility and invasiveness of pancreatic ductal adenocarcinoma cells PMID: 27453460
- Vav3 inhibition can suppress cell activity and promote apoptosis by regulating the apoptosis-related genes through the ERK pathway PMID: 26695150
- Data show that microRNA miR-499-5p targeted 3' untranslated regions (3'-UTR) of vav 3 oncogene protein (VAV3). PMID: 26972445
- Results found that OSR2, VAV3, and PPFIA3 were significantly hypermethylated in gastric cancer (GC) patients offering a good alternative in a simple, promising, and noninvasive detection of GC. PMID: 27143812
- Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3, APOA1, and VAV3, except for VGF protein, there was a trend between the expression of these four genes and their protein levels. PMID: 26337083
- VAV3 overexpression is a novel biomarker for poor prognosis and survival in ovarian carcinoma. PMID: 25715123
- VAV3 overexpression could be a useful marker for predicting the outcomes of CRC patients and that VAV3 targeting represents a potential modality for treating CRC PMID: 25791293
- discrete and different functions of VAV3.1 in metastasis and tumorigenesis are conceivable. PMID: 25964534
- Inhibition of Vav3 could reverse the drug resistance of gastric cancer cells by downregulating JNK signaling pathway. PMID: 25430880
- This study proposes VAV3 as a biomarker and a rationale for its use as a signaling target to prevent and/or overcome resistance to endocrine therapy in breast cancer. PMID: 24886537
- A new genome-wide significant association between VAV3 and IgA nephropathy. PMID: 25305756
- Data indicate that Vav3 oncogene protein plays a crucial role in prostate cancer growth and malignant behavior, and could be a potential therapeutic target. PMID: 23403204
- Vav3 is involved in the proliferation, migration, and invasion of gastric cancer cell as a tumor oncogene PMID: 24072493
- Interrupting Vav3 signaling enhances docetaxel-induced apoptosis in LNCaP cells under chronic hypoxia by inhibiting the PI3K/Akt, ERK, and AR signaling pathways. PMID: 23566222
- VAV3 can be seen as novel candidate gene for schizophrenia in which both rare and common variants may be related to increased genetic risk in a Japanese population. rs1410403 might affect the volume of the left temporal gyri. PMID: 22416266
- Two variants of VAV2 and VAV3, rs2156323 and rs2801219, respectively, were identified in Japanese patients with primary open angle glaucoma, normal tension glaucoma, and developmental glaucoma. PMID: 23402756
- These data, which demonstrate physical and functional interactions between Vav3 and an AR splice variant, provide insights into the mechanisms by which Vav3 exploits and enhances AR signaling in the progression to castration-resistant prostate cancer. PMID: 23023561
- analysis of a novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth PMID: 23281476
- Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 and Vav3 play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis. PMID: 23033535
- Data indicate that Vav2 and Vav3 controlled a vast transcriptional program in breast cancer cells through mechanisms that were shared between the two proteins, isoform-specific or synergistic. PMID: 23033540
- Study suggests that overexpression of guanine nucleotide exchange factor Vav3 can be a useful marker for predicting the outcome of patients with gastric cancer and that Vav3 targeting can represent a potential modality for treating gastric cancer. PMID: 22544459
- Novel associations for hypothyroidism and autoimmune risk loci include SNPs near the VAV3 gene. PMID: 22493691
- Among patients with stage IIB or earlier prostate cancer, higher Vav3 expression correlated with lower cumulative biochemical failure-free survival, suggesting that Vav3 may represent a prognostic marker for posttreatment recurrence of prostate cancer. PMID: 22659453
- Data show the importance of Vav3 in castration-resistant prostate cancer (CRPC) and define a nuclear function of Vav3 in regulating androgen receptor (AR) activity. PMID: 21765461
- These data revealed that Vav3 overexpression as an additional underlying mechanism contributes to elevated sPLA2-IIa expression in prostate cancer PMID: 21455584
- Vav3 may enhance non-genomic AR activity via PI3K-Akt signaling in addition to AR transcriptional activity, showing that it may have a role in androgen-independent growth in prostate cancer PMID: 20126983
- present data indicate a lack of involvement of variations in NTF4, VAV2, and VAV3 with glaucoma pathogenesis in an Indian population. PMID: 20463313
- Data strongly suggest that VAV2 and VAV3 genes are susceptibility loci in Japanese primary open-angle glaucoma. PMID: 20140222
- Vav3 regulates the B cell responses by promoting the sustained production of PIP3 and thereby calcium flux PMID: 11805146
- We present here a novel stimulatory mechanism of Vav3 in which APS directly relieves the autoinhibitory CH domain and furthermore enhances its tyrosine phosphorylation by Lck. PMID: 12400014
- results demonstrate that Vav3 and Vav1 play crucial but redundant roles in the activation of phospholipase C gamma 2 by glycoprotein GPVI PMID: 15456756
- TCR-induced association of Vav3 with SLP-76 is required for its membrane/IS localization and function PMID: 15708849
- Vav3 levels rise during prostate cancer progression to androgen independence. PMID: 16384856
- Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer development and progression. PMID: 16762975
- Constitutively active Vav3 mediates ligand-independent transcriptional activation and promotes nuclear localization pf the androgen receptor in prostate neoplsms. PMID: 18079321
- Findings suggest that Vav3 overexpression may aberrantly enhance ERalpha-mediated signaling axis and play a role in breast cancer development and/or progression. PMID: 18518979
- Data show that Trio, Ect2, and Vav3 are expressed at higher levels in glioblastoma versus low-grade glioma, and are involved in tumor cell migration and invasion. PMID: 19008376
- Proteins beta3 integrin, Vav3, Plekhm1, and Src, implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis. PMID: 19546854
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組織特異性：Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, f
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