BRINP1 Antibody
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中文名稱：BRINP1兔多克隆抗體
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貨號：CSB-PA006515GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：BRINP1
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別名：BMP/retinoic acid-inducible neural-specific protein 1 antibody; BRINP1 antibody; DBC1 antibody; DBC1_HUMAN antibody; DBCCR1 antibody; Deleted in bladder cancer protein 1 antibody; Deleted in bladder cancer protein 1 precursor antibody; FAM5A antibody; IB3089A antibody; Protein FAM5A antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human DBC1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.
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基因功能參考文獻：
- Results found that the expression of DBCCR1 is significantly lower in the lung cancer tissues compared with adjacent non-tumor tissues of patients, and correlates with more advanced stages of cancer, and shorter survival of patients. Interestingly, DBCCR1 attenuates the expression of DNMT1, suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation. PMID: 28427182
- we found that the SIRT1 modulators AROS and DBC1 have an impact on hsp70 transcription, HSF1 acetylation status, and HSF1 recruitment to the hsp70 promoter PMID: 23349863
- DBC1 modulates the stability and function of the nuclear receptor Rev-erb-alpha. PMID: 23398316
- the stress-induced DBC1-SIRT1 interaction is important for cell fate determination following genotoxic stress. PMID: 22465953
- Rxpression of DBC1 and SIRT1 is a significant prognostic indicator for breast carcinoma patients. PMID: 21056897
- High DBC1 expression is associated with breast and lung cancer.. PMID: 20429629
- DBCCR1 is involved in the process of bladder tumorigenesis PMID: 12442002
- the prevalent inactivation of DBCCR1 seen at the expression level in astrocytomas is not primarily caused by genomic loss of the gene. PMID: 15643521
- likely tumor suppressor for NSCLC;silencing through homozygous deletion or methylation of its promoter promotes progression PMID: 15746151
- hypermethylation of the DBC1 promoter region is a frequent event during the development of lymphoproliferative malignancies PMID: 18264085
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亞細胞定位：Cytoplasm.
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蛋白家族：BRINP family
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組織特異性：Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.
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數(shù)據(jù)庫鏈接：
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