NPR3 Antibody

中文名稱：

NPR3兔多克隆抗體
貨號：

CSB-PA016025LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA016025LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA016025LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NPR3 Polyclonal antibody
Uniprot No.：

P17342
基因名：

NPR3
別名：

NPR3; ANPRC; C5orf23; NPRC; Atrial natriuretic peptide receptor 3; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Atrial natriuretic peptide receptor 3 protein (36-127AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NPR3 Antibody (CSB-PA016025LA01HU)，的標記方式是Non-conjugated。對于NPR3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA016025LB01HU	NPR3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA016025LC01HU	NPR3 Antibody, FITC conjugated
Biotin	CSB-PA016025LD01HU	NPR3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
基因功能參考文獻：
1. NPR3 expression is downregulated by MRCCAT1 in the in metastatic clear cell renal cell carcinoma. PMID: 28659173
2. This study suggested that NPR3 rs2270915 polymorphism was associated with decreased systolic blood pressure level marginally in essential hypertension patients in a Chinese Han population; the polymorphism may function through decreasing NPR3 mRNA expression and ANP level. PMID: 28497617
3. NPR-C gene single nucleotide polymorphisms significantly contribute to CAD susceptibility in the Chinese Han population PMID: 27191271
4. The NPRC genetic variant,Rs1847018, is a genetic marker of essential hypertension. PMID: 26782497
5. This study focused on the natriuretic peptide receptor C gene (NPR3). The correlation analysis between NPR3 and hypertension was replicated in 450 Chinese Dai and 484 Chinese Mongolian individuals. PMID: 26345810
6. Angiotensin II downregulates vascular smooth muscle cell NPR-C gene expression by destabilizing its mRNA. PMID: 25711724
7. Results from this study point to a role for miR-100 in the regulation of NPR3 expression, and suggest a possible therapeutic target for modulation of NP bioactivity in heart disease. PMID: 25736855
8. Data show that natriuretic peptide receptor 3 (NPR3) single nucleotide polymorphism (SNP) is independently associated with diastolic dysfunction and does not appear to be related to alterations in circulating levels of natriuretic peptides. PMID: 24465655
9. The significant change in NPR3 protein was observed for the Arg146 variant allozyme, with 20% of wild-type protein, primarily because of autophagy-dependent degradation. PMID: 23493048
10. polymorphisms or haplotype in NPR3 gene may influence the risk of ischemic stroke or hypertension independently in Chinese population. PMID: 22559095
11. a NPR3 promoter gene variant could have a role on cerebrovascular disease susceptibility PMID: 22995222
12. Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery, with increased expression of NPR3 in histologically unstable plaques. PMID: 22421372
13. Data found a consistent and significant association between the rs2270915 polymorphism of the NPR3 gene and SBP in diabetic patients. This genetic variation may affect pressure response to changes in dietary sodium. PMID: 21464461
14. integrative genomics approach to a large cohort of medulloblastomas has identified four disparate subgroups (NPR3)with distinct demographics, clinical presentation, transcriptional profiles, genetic abnormalities, and clinical outcome. PMID: 20823417
15. The mRNA levels of natriuretic peptide receptor-C appear to be increased in epicardial adipose tissue independent of their plasma levels in coronary artery disease. PMID: 20691218
16. The novel Npr1 gene 3C variant and the Npr3 gene C(-55) allele are associated with hypertensive family history. PMID: 12872042
17. Atrial natriuretic paptide, purified from medium bathing cells expressing NPR-C, a receptor known to internalize natriuretic peptides, was degraded. PMID: 15459247
18. Novel six-nucleotide repeat polymorphism located 4 base pairs upstream of the major transcriptional initiation site. PMID: 15785005
19. model of hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C [review] PMID: 15911071
20. discussion of NPR-C receptor coupling to different signaling pathways and their regulation [review] PMID: 15911072
21. A structural comparison of complexes of NPC-C with each NP hormones (ANP, BNP, and CNP)reveals that NPR-C uses a conformationally inflexible surface to bind three different, highly flexible, NP ligands. PMID: 16870210
22. The NPRC polymorphism is not an independent determinant of NP concentration in HF. PMID: 17890443
23. the NPR-C receptor is expressed in normal and neoplastic human alpha cells. PMID: 19352691
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

ANF receptor family
數據庫鏈接：

HGNC: 7945

OMIM: 108962

KEGG: hsa:4883

STRING: 9606.ENSP00000265074

UniGene: Hs.13528

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