Recombinant Varicella-zoster virus Alpha trans-inducing factor 74 kDa protein (ORF12)

in vitro E.coli expression system

中文名稱：

Recombinant Varicella-zoster virus Alpha trans-inducing factor 74 kDa protein(ORF12)
貨號(hào)：

CSB-CF678618VAQ
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

ORF12
Uniprot No.：

Q4JQW3
別名：

ORF12; Tegument protein UL46 homolog; Tegument protein VP11/12 homolog
種屬：

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-661
氨基酸序列

MFSRFARSFSSDDRTRKSYDGSYQSFNAGERDLPTPTRDWCSISQRITSERVRDGCLIPT PGEALETAVKALSEKTDSLTSPVLQSTERHSVLLGLHHNNVPESLVVSCMSNDVHDGFMQ RYMETIQRCLDDLKLSGDGLWWVYENTYWQYLKYTTGAEVPVTSEKVNKKSKSTVLLFSS VVANKPISRHPFKSKVINSDYRGICQELREALGAVQKYMYFMRPDDPTNPSPDTRIRVQE IAAYTATGYGWMLWFLDVVDARVCRHLKLQFRRIRGPRASVIPDDLLRRHLKTGPAVSAG TGVAFILAATTASALTALLRISVLWRKEEWRDGLNGTAAAIVAAVELITLLHHHFQYLIN MMLIGYACWGDGGLNDPYILKALRAQGRFLYFAGQLVRTMSTHSWVVLETSTHMWFSRAV AQSILAHGGKPTKYYAQVLAASKRYTPLHLRRISEPSSVSDQPYIRFNRLGSPIGTGIGN LECVCLTGNYLSDDVNASSHVINTEAPLNSIAPDTNRQRTSRVLVRPDTGLDVTVRKNHC LDIGHTDGSPVDPTYPDHYTRIKAEYEGPVRDESNTMFDQRSDLRHIETQASLNDHVYEN IPPKEVGFNSSSDLDVDSLNGYTSGDMHTDDDLSPDFIPNDVPVRCKTTVTFRKNTPKSH H
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Plays a role in the activation of the host PI3K/AKT pathway to promote cell survival. Interacts with and activates PI3KR1 in order to phosphorylate host AKT on its activating residues. Activates the host AP-1 pathway by triggering phosphorylation of host ERK1/2. Participates in host BIM and BAD phosphorylation, leading to apoptosis inhibition.
基因功能參考文獻(xiàn)：
1. In conclusion, authors have found that the varicella-zoster virus ORF12 protein activates the PI3K/Akt pathway to regulate cell cycle progression. PMID: 23192871
2. Varicella-Zoster virus ORF12 protein triggers phosphorylation of ERK1/2 and inhibits apoptosis. PMID: 22238304
亞細(xì)胞定位：

Virion tegument. Host cytoplasm. Host membrane; Multi-pass membrane protein.
蛋白家族：

Herpesviridae HHV-1 VP11/12 protein family
數(shù)據(jù)庫(kù)鏈接：

KEGG: vg:1487655