Recombinant Resistance to inhibitors of cholinesterase protein 3 (ric-3)

in vitro E.coli expression system

中文名稱：

秀麗隱桿線蟲ric-3重組蛋白
貨號：

CSB-CF631507CXY
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

ric-3
Uniprot No.：

Q22472
別名：

ric-3; des-5; T14A8.1; Resistance to inhibitors of cholinesterase protein 3
種屬：

Caenorhabditis elegans
蛋白長度：

full length protein
表達區域：

1-378
氨基酸序列

MPKTERRRDRDRDRDRERRNRRKRDDSYDDYDEEGGISGWKLGLVFGVIVVCFAMLYPTL FHPMLMGFLGRSPPSSPSINQQRPPIHPAMGGGSGQRHPGGGADVHPAMRMAQAQAESQS GGSKGMFTWMLPVYTIGVVLFLLYTLFKSKGKKSKRKKRNYFDSEDDDDESESETKYGGK FGKKKLEGLQKRLRETESAMSKILEQLESVQAGANPVDLDAADKRSEQLEEDPSVKEAVG LTETNEQYIKDLEVALKEFQSLSKEYDKAKMKKLKRKDSSSDEDEEDEEENSSELSEIEE EEEEVKPVKKSKSSSQSVGKRKNRPKSTSEEEDEGEEESRKVAEDAEEEGIDIDSEIREH AEKEKKDKNVRRRRPKKT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for maturation and cell surface expression of acetylcholine receptors.
基因功能參考文獻：
1. RIC-3 phosphorylation at Ser-164 depends on opposing functions of the phosphatase calcineurin (TAX-6), and of the casein kinase II homologue KIN-10. RIC-3 phosphorylation enables effects of this chaperone on GABAA receptors in addition to nAChRs. PMID: 27489343
2. The conserved residues in the second RIC-3 transmembrane domain are needed for its interactions with DEG-3,DES-2 and ACR-16. PMID: 19899809
3. subunit-specific interactions of RIC-3 with nAChR subunits DEG-3/DES-2, mediated by the transmembrane domains, are sufficient for the effects of RIC-3 on nAChR quantity and quality PMID: 15932871
4. RIC-3 alternative splicing enables subtype specific regulation of nicotinic acetylcholine receptor maturation. PMID: 19116311
亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

Ric-3 family
組織特異性：

Expressed in pharyngeal muscles, body wall muscles and in most neurons.
數據庫鏈接：

KEGG: cel:CELE_T14A8.1

STRING: 6239.T14A8.1

UniGene: Cel.6773