Recombinant Rat Sodium channel subunit beta-2 (Scn2b)

in vitro E.coli expression system

中文名稱：

大鼠Scn2b重組蛋白
貨號：

CSB-CF020838RA
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Scn2b
Uniprot No.：

P54900
別名：

Scn2b; Sodium channel subunit beta-2
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

30-215
氨基酸序列

MEVTVPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECSNCSEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNAEDGAK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.
基因功能參考文獻：
1. Navbeta2 is a critical regulator of axonal excitability and synaptic function. PMID: 28871036
2. distribution of SCN2B-containing neurons in the trigeminal ganglion PMID: 26852328
3. miR-9 suppressed the trafficking of Nav1.1/Nav1.2 from cytoplasm to cell membrane. miR-9 overexpression inhibited Navbeta2 expression by targeting its coding sequence domain. PMID: 26259688
4. Through its role in regulating density of mature voltage-gated sodium channels in plasma membrane and modulating channel gating, beta2 subunit may affect development of ectopic activity in injured and non-injured sensory afferents and neuropathic pain. PMID: 16306410
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Sodium channel auxiliary subunit SCN2B (TC 8.A.17) family
組織特異性：

Brain specific.
數據庫鏈接：

KEGG: rno:25349

STRING: 10116.ENSRNOP00000021819

UniGene: Rn.88636