Recombinant Rat Potassium voltage-gated channel subfamily C member 1 (Kcnc1)

in vitro E.coli expression system

中文名稱：

大鼠Kcnc1重組蛋白
貨號(hào)：

CSB-CF012018RA
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

Kcnc1
Uniprot No.：

P25122
別名：

Kcnc1; Potassium voltage-gated channel subfamily C member 1; NGK2; RAW2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4
種屬：

Rattus norvegicus (Rat)
蛋白長(zhǎng)度：

Full length protein
表達(dá)區(qū)域：

1-585
氨基酸序列

MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE TEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH HSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTR ERYGPCFLLSTGEYACPPGGGMRKDLCKESPVIAKYMPTEAVRVT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
基因功能參考文獻(xiàn)：
1. Trafficking-dependent roles of the Kv3.1b potassium channel are dependent on N229 site-specific glycosylation and N-glycan structure, and operate through a mechanism whereby specific N-glycan structures regulate cell surface expression. PMID: 28322444
2. This study demonstrated that Kv3.1b potassium channel expression in motor cortex pyramidal cells. PMID: 28213922
3. Our findings provide direct evidence that N-glycans of Kv3.1 splice variants contribute to the placement of these glycoproteins in the plasma membrane of neuronal-derived cells while those of Kv1.1 were absent. PMID: 26348848
4. Results indicate that Src kinase may play an important role in regulating membrane trafficking of Kv3.1b channels. PMID: 24291260
5. high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B requires three basic residues in the KIF5B tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1), for binding to the KIF5B tail. PMID: 23487040
6. The unique N-terminus of DPP6K modulates the effects of KChIP proteins, slowing recovery and producing a negative shift in the steady-state inactivation curve. PMID: 22675523
7. alternative splicing controls neuronal firing rates by regulating the polarized targeting of Kv3.1 channels. PMID: 22105078
8. These results have demonstrated that N-glycans of the Kv3.1 glycoprotein enhance outward ionic current kinetics, and neuronal migration. PMID: 21541302
9. study to elucidate the relative distribution of Kv3.1b and Kv3.3 in specific compartments of the parallel fibers in the cerebellar cortex PMID: 20857303
10. A previously unknown interaction between the KV4 channel and Kv channel interacting protein (KChIP)3 in Muller cells could exert a physiological role in the onset of diabetic retinopathy. PMID: 21147063
11. Net amounts of Kv3.1b protein can change on a time scale of minutes in response to stimulus-driven synaptic activity, permitting auditory neurons to actively adapt their complement of ion channels to changes in the acoustic environment. PMID: 20219640
12. Kv3-like currents may be important for maintaining spike width and calcium influx within acceptable limits during repetitive firing. PMID: 15240761
13. Synaptic inputs evoked by stimulation of a region lacking Kv3.1b-IR neurons were not affected, correlating the presence of Kv3.1b in the tractus solitarius with the pharmacological effects. [Kv3.1b] PMID: 15528247
14. Both fast-firing and burst-firing parvalbumin+ interneurons in the basolateral amygdala express the Kv3.1b subunit. PMID: 16413129
15. the Kv3.1b channel is regulated by both conventional and novel PKC isozymes, and novel PKC-delta contributes specifically to the maintenance of basal phosphorylation in auditory neurons PMID: 16595659
16. The axon-dendrite targeting of Kv3.1 Shaw channel is controlled by a conditional interaction of a C-terminal axonal targeting motif with the N-terminal T1 domain and adaptor protein ankyrin G. PMID: 18094255
17. Suggest that fluoxetine acts on Kv3.1 currents as an open-channel blocker. PMID: 18187934
18. The results suggest that an altered expression of Kv3 channels affects the functional properties of FS neurons, and may contribute to the deficits in inhibition observed in the sensory-deprived cortex. PMID: 18708127
19. Report effect of psoralen on the cloned Kv3.1 currents. PMID: 19387585
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane.
蛋白家族：

Potassium channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.1/KCNC1 sub-subfamily
組織特異性：

Expressed in brain. Expressed in globus pallidal neurons of the basal ganglia (at protein level). Detected on Purkinje cells in the cerebellum molecular layer (at protein level).
數(shù)據(jù)庫(kù)鏈接：

KEGG: rno:25327

STRING: 10116.ENSRNOP00000015260

UniGene: Rn.33095