Recombinant Rat Platelet-activating factor receptor (Ptafr)

in vitro E.coli expression system

中文名稱：

大鼠Ptafr重組蛋白
貨號：

CSB-CF018946RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Ptafr
Uniprot No.：

P46002
別名：

Ptafr; Platelet-activating factor receptor; PAF-R; PAFr
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區(qū)域：

1-341
氨基酸序列

MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLT VADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVA YPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPY SVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAV FVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFR KHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
基因功能參考文獻：
1. In hypoxic tissue, PAFR protein expression is up-regulated, but is reduced in the bilobalide treated tissue. PMID: 21391918
2. These data show the histological localization of PAF synthases and its receptor in the spinal cord following peripheral nerve injury. PMID: 22296727
3. PAF inhibition interkinetic nuclear migration (IKNM) in retinal proliferating progenitors depended on the PAF receptor, Erk and p38 pathways and Chk1 PMID: 21298035
4. differential activation of both G(i) and G(q) by PAFR likely mediate specific as well as redundant signaling pathways PMID: 16920964
5. PAF receptor gene expression may be subject to down-regulation in the perifocal regions of cerebral infarction after cerebral ischemia-reperfusion. PMID: 17268849
6. Platelet activating factor receptor (PAF-R) plays an important role in occurrence and development of severe acute pancreatitis. BN52021 exerts biological effects through competitively inhibiting the binding of increased both PAF and PAF-R expression. PMID: 17589953
7. Cirrhosis sensitizes hepatic stellate cells to PAF by elevating its receptor level PMID: 18186558
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Present in almost all organs including spleen, small intestine, kidney, lung, liver and brain.
數(shù)據(jù)庫鏈接：

KEGG: rno:58949

STRING: 10116.ENSRNOP00000017687

UniGene: Rn.10137