Recombinant Rat Phospholemman (Fxyd1)

in vitro E.coli expression system

中文名稱：

大鼠Fxyd1重組蛋白
貨號(hào)：

CSB-CF009089RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

Fxyd1
Uniprot No.：

O08589
別名：

Fxyd1; Plm; Phospholemman; FXYD domain-containing ion transport regulator 1; Sodium/potassium-transporting ATPase subunit FXYD1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

21-92
氨基酸序列

EAPQEPDPFTYDYHTLRIGGLTIAGILFILGILIILSKRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.
基因功能參考文獻(xiàn)：
1. Data suggest Ncx1 (sodium-calcium exchanger 1) is substrate-specifying Pp1c (protein phosphatase 1c) regulator protein, regulating Ncx1 activity via Ser-68-Plm dephosphorylation in cardiomyocytes; Plm/Ncx1/Pp1c complex is up-regulated in heart failure. PMID: 26668322
2. PLM exists as a pump-inhibiting monomer and an unassociated oligomer. PMID: 23532852
3. Chronic nicotine modifies skeletal muscle Na,K-ATPase activity through its interaction with the nicotinic acetylcholine receptor and phospholemman. PMID: 22442718
4. role of protein phosphatase-1 on phospholemman phosphorylation and Na/K-ATPase activity in cardiomyocytes PMID: 21849407
5. palmitoylation of PLM controls its turnover, and palmitoylated PLM inhibits the sodium pump. PMID: 21868384
6. Report altered expression of Na(+)-K(+) pump subunits, FXYD1 and NHE1 depending on training status, intensity and muscle type. PMID: 21325644
7. hypertonic activation of this protein in solitary rat hepatocytes in primary culture PMID: 12606048
8. Expression in the extraglomerular mesangial cells and juxtaglomerular apparatus arterioles PMID: 12657562
9. Myocardial ischemia-induced phosphorylation of phospholemman directly activates cardiac Na/K-ATPase. PMID: 14597563
10. PLM phosphorylation at Ser68 may be involved in cAMP- and/or protein kinase C-dependent regulation of cardiac contractility. PMID: 15653756
11. In skeletal muscle, PLM appears to be a protein integral to the Na+-K+-ATPase(NKA) complex, and PLM has the potential to modulate NKA in an isoform-specific and muscle type-dependent manner in aging and after exercise training. PMID: 15961612
12. These results suggest that FXYD1 contributes to facilitating the advent of puberty by maintaining GnRH neuronal excitability to incoming transsynaptic stimulatory inputs. PMID: 19187398
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亞細(xì)胞定位：

Cell membrane, sarcolemma; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Membrane, caveola. Cell membrane, sarcolemma, T-tubule.
蛋白家族：

FXYD family
組織特異性：

In adult brain, highest levels are found in the cerebellum and in the lateral, third and fourth ventricles of the choroid plexus (at protein level). Also detected in cells of a portion of the ependymal lining of the lateral ventricle on its rostral surfac
數(shù)據(jù)庫鏈接：

STRING: 10116.ENSRNOP00000028624

UniGene: Rn.3828