Recombinant Rat Histamine H4 receptor (Hrh4)

in vitro E.coli expression system

中文名稱：

大鼠Hrh4重組蛋白
貨號：

CSB-CF835611RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Hrh4
Uniprot No.：

Q91ZY1
別名：

Hrh4; Histamine H4 receptor; H4R; HH4R
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區(qū)域：

1-391
氨基酸序列

MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAIS DFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAV RYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAIT AFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSL PGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRG RKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLY PLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
基因功能參考文獻：
1. the present study found that blocking H4R exerted a significant anti-inflammatory effect at 2 h after Lipopolysaccharide injection and inhibited pro-inflammatory Tumor Necrosis Factor-alpha- and NF-kappaB expression PMID: 25666529
2. Data indicate that positive histamine H4 receptor (HRH4) immunostaining was detected in Leydig cells of all testicular sections. PMID: 25253872
3. The H4 receptor is expressed in the kidney mainly by resident renal cells of the loop of Henle and is significantly overexpressed in diabetic animals, suggesting a possible role in the pathogenesis of diabetes-associated renal disease PMID: 23262779
4. Histamine inhibits lipopolysaccharide-induced interleukin (IL)-1beta release in hippocampal organotypic slice cultures. PMID: 22569158
5. H4 receptors are the primary receptors involved in effective histaminergic regulation of the excitability of vestibular primary neurons. PMID: 22624822
6. analysis of fragment optimization and analysis of binding kinetics for ligand based design of novel histamine H receptor antagonists PMID: 22153663
7. The present data suggest for the first time a possible ulcerogenic role mediated by histamine H4 receptors in the rat gastric mucosa PMID: 21839070
8. Histamine H4 receptor is closely related with allergic rhinitis and is important in the pathogenesis of allergic rhinitis. PMID: 21055325
9. H(4) mRNA was detected in cortex, cerebellum, brainstem, amygdala, thalamus & striatum; low levels were detected in hypothalamus, & none was detected in the hippocampus; strong expression of H(4) mRNA was detected in dorsal root ganglion & spinal cord PMID: 19046950
10. analysis of how quinazolines can act as histamine H4 receptor inverse agonists PMID: 19053770
11. Results do not suggest a role for histamine H4 receptors in the control of intestinal neurotransmission in the rat. PMID: 19271139
12. Histamine H4 receptors are functionally expressed on neurons, which has major implications for the therapeutic potential of these receptors in neurology and psychiatry. PMID: 19413571
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數(shù)據(jù)庫鏈接：

KEGG: rno:170704

STRING: 10116.ENSRNOP00000022744

UniGene: Rn.162272