Recombinant Rat Hepatitis A virus cellular receptor 1 homolog (Havcr1)

in vitro E.coli expression system

中文名稱：

大鼠Havcr1重組蛋白
貨號：

CSB-CF010144RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Havcr1
Uniprot No.：

O54947
別名：

Havcr1; Kim1; Hepatitis A virus cellular receptor 1 homolog; HAVcr-1; Kidney injury molecule 1; KIM-1; T cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; CD antigen CD365
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

22-307
氨基酸序列

YEVVKGVVGHPVTIPCTYSTRGGITTTCWGRGQCPYSSCQNILIWTNGYQVTYRSSGRYNIKGRISEGDVSLTIENSVDSDSGLYCCRVEIPGWFNDQKMTFSLEVKPEIPTSPPTRPTTTRPTTTRPTTISTRSTHVPTSTRVSTSTPTPEQTQTHKPEITTFYAHETTAEVTETPSYTPADWNGTVTSSEEAWNNHTVRIPLRKPQRNPTKGFYVGMSVAALLLLLLASTVVVTRYIIIRKKMGSLSFVAFHVSKSRALQNAAIVHPRAEDNIYIIEDRSRGAE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair.
基因功能參考文獻：
1. High KIM1 expression is associated with decreased proximal tubular epithelial cell function. PMID: 29045706
2. urinary KIM1 may be a valuable biomarker for the early diagnosis of obstructive AKI, and the use of a colloidal gold immunochromatographic strip may be a promising method for the rapid detection of urinary KIM1. PMID: 28075469
3. Results show that in contrast to other known molecules indicating renal injury and/or repair mechanisms, the chronic renal expression of Kim-1 is strictly confined to proximal cysts. PMID: 27231899
4. blood biomarker that specifically reflects acute and chronic kidney injury PMID: 24904085
5. Ischemic postconditioning can attenuate the renal ischemia reperfusion injury and downregulate the expression of Kim-1. PMID: 22898836
6. These studies are the first direct demonstration of regulation of KIM-1 in response to oxalate exposure in renal epithelial cells in vitro and in vivo. PMID: 22984472
7. The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary alpha-GST and KIM-1. PMID: 21905055
8. The Kim1 gene is regulated in an epigenetic fashion under conditions of nephrotoxicity. PMID: 20660082
9. Results show Kim-1 outperforms SCr, BUN and urinary NAG in multiple rat models of kidney injury. PMID: 20458318
10. KIM-1 as a sensitive molecular marker of different levels of tubular injury PMID: 20305092
11. Urinary Kim-1 serve as a noninvasive, rapid, sensitive, reproducible method to detect early kidney injury in pathophysiological studies and in preclinical drug development studies for risk-benefit profiling of pharmaceutical agents. PMID: 16174863
12. These results implicate involvement of kidney injury molecule 1 (Kim-1) in the pathogenesis of proteinuria-induced renal damage/repair. Urinary Kim-1 levels may serve as a marker of proteinuria-induced renal damage. PMID: 16467126
13. Kim-1 is associated with development of renin-angiotensin system-mediated renal damage PMID: 16896183
14. Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury PMID: 17934191
15. Data demonstrate that injured kidney epithelial cells assumed attributes of endogenous phagocytes, and that KIM-1 was directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and also porcine and canine epithelial cell lines. PMID: 18414680
16. on longitudinal follow-up during antiproteinuric treatment increased renal Kim-1 expression is reversible in proportion to proteinuria reduction, likely reflecting reversibility of early tubular injury PMID: 19225054
17. Cadmium-induced increase in Kim-1 expression occurs before the onset of necrosis and at a point where there is only a modest level of apoptosis in the proximal tubule. PMID: 19371613
18. Kim-1 is a sensitive biomarker of the early stages of Cadmium-induced proximal tubule injury. PMID: 19371616
19. Dipsticks can provide a sensitive and accurate detection of Havcr1. PMID: 19387469
20. Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage. PMID: 19522876
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Immunoglobulin superfamily, TIM family
組織特異性：

Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules.
數(shù)據(jù)庫鏈接：

KEGG: rno:286934

STRING: 10116.ENSRNOP00000009573

UniGene: Rn.11154